Evidence map›Paper›PMID 33604569›Full record

ArticleBrain communications2021

Melatonin and/or erythropoietin combined with hypothermia in a piglet model of perinatal asphyxia.

Raymand Pang, Adnan Avdic-Belltheus, Christopher Meehan, Kathryn Martinello, Tatenda Mutshiya, Qin Yang, Magdalena Sokolska, Francisco Torrealdea, Mariya Hristova, Alan Bainbridge and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Melatonin treatment for neonatal encephalopathy.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia.Annals of clinical and translational neurology · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Raymand PangDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-2004-6650
Adnan Avdic-BelltheusDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.
Christopher MeehanDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.
Kathryn MartinelloDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-7490-7313
Tatenda MutshiyaDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.
Qin YangDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-9613-688X
Magdalena SokolskaDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK.
Francisco TorrealdeaDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK.
Mariya HristovaDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.
Alan BainbridgeDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK.
Xavier GolayDepartment of Brain Repair and Rehabilitation, Institute of Neurology, Queen's Square, University College London, London, UK.
Sandra E JuulDepartment of Pediatrics, University of Washington, Seattle, Washington, DC, USA.
Nicola J RobertsonDepartment of Neonatology, Institute for Women's Health, University College London, London, UK.
London Women's Clinic · GBRoyal London Hospital · GBQueen Mary University of London · GBUniversity of Washington · US

Funding

Medical Research Council MR/P025978/1
6 · The paper itself

Abstract

As therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We hypothesized that melatonin and erythropoietin individually augment 12-h hypothermia (

Indexed as

erythropoietinmelatoninneonatal encephalopathyneuroprotectiontherapeutic hypothermia

Identifiers

PMID33604569
PMCPMC7876304
OpenAlexW3107058825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.