Evidence map›Paper›PMID 33604532›Full record

ArticleJHEP reports : innovation in hepatology2021

ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis.

Jeffrey C To, Amy P Chiu, Barbara R Tschida, Lilian H Lo, Cynthia H Chiu, Xiao-Xiao Li, Timothy P Kuka, Michael A Linden, Khalid Amin, Wing-Cheung Chan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 48 citations in OpenAlex.

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  15. Editorial: Hormone resistance in cancer.Frontiers in endocrinology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jeffrey C ToDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Amy P ChiuDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Barbara R TschidaMasonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Lilian H LoDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Cynthia H ChiuDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Xiao-Xiao LiDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Timothy P KukaMasonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Michael A LindenDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Khalid AminDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Wing-Cheung ChanDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Jason B BellMasonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Branden S MoriarityMasonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
David A LargaespadaMasonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Vincent W KengDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Hong Kong Polytechnic University · HKUniversity of Minnesota · USThe University of Texas at Austin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsZinc finger and BTB domain containing 20 (

methodsA reverse genetic study using the Sleeping Beauty (

resultsTransgenic overexpression of

conclusionsThese findings demonstrate a novel interaction between ZBTB20 and PPARG, which leads to activation of the WNT/CTNNB1 signalling pathway in HCC tumourigenesis. LAY SUMMARY:

Indexed as

AFP, alpha-foetoproteinBTB/POZ, broad complexCTNNB1CTNNB1, catenin beta 1Fah, fumarylacetoacetate hydrolaseGSK3B, glycogen synthase kinase 3 betaHCC, hepatocellular carcinomaHepatocellular carcinomaHHL, immortalized human hepatic cell lineIF, immunofluorescenceNTBC, 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedioneOFP, orange fluorescent proteinPHI, post-hydrodynamic injectionPOK, POZ and KruppelPPARGPPARG, peroxisome proliferator activated receptor gammaqPCR, quantitative RT-PCRReverse genetic screenSB, Sleeping BeautySleeping Beautytramtrack, bric a brac/poxvirus and zinc fingerZBTB20ZBTB20, zinc finger and BTB domain containing 20

Identifiers

PMID33604532
PMCPMC7873381
OpenAlexW3111471410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.