Evidence map›Paper›PMID 33604458›Full record

ArticleClinical and translational radiation oncology2021

Concurrent paclitaxel and radiation therapy for the treatment of cutaneous angiosarcoma.

Amit Roy, Prashant Gabani, Elizabeth J Davis, Peter Oppelt, Emily Merfeld, Vicky L Keedy, Imran Zoberi, John S A Chrisinger, Jeff M Michalski, Brian Van Tine and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03921008 (Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03921008 phase1 / phase2active not recruitingnot on this map

Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma

TypeinterventionalSponsorWashington University School of MedicineRan2019 to 2028Enrolled20ConditionsCutaneous AngiosarcomaArmsPaclitaxel, Radiation therapy, Research blood draw
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Successful surgical treatment for primary cardiac angiosarcoma: a case report.General thoracic and cardiovascular surgery cases · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. Management of Cutaneous Angiosarcoma: an Update Review.Current treatment options in oncology · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Amit RoyDepartment of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Prashant GabaniBaylor Scott and White Health Cancer Center, 300 University Blvd., Bldg. A, Round Rock, TX 78665, United States.
Elizabeth J DavisDepartment of Hematology and Oncology, Vanderbilt University School of Medicine, 1161 21st Ave S # D3300, Nashville, TN 37232, United States.
Peter OppeltDivision of Medical Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Emily MerfeldDepartment of Human Oncology, University of Wisconsin School of Medicine, 600 Highland Ave, Madison, WI 53792, United States.
Vicky L KeedyDepartment of Hematology and Oncology, Vanderbilt University School of Medicine, 1161 21st Ave S # D3300, Nashville, TN 37232, United States.
Imran ZoberiDepartment of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
John S A ChrisingerDepartment of Pathology and Immunology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Jeff M MichalskiDepartment of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Brian Van TineDivision of Medical Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Matthew B SprakerDepartment of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States.
Washington University in St. Louis · USVanderbilt University · USBaylor Scott & White Health · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe compared clinical outcomes in patients with cutaneous angiosarcoma receiving concurrent paclitaxel-based chemoradiotherapy (CRT) vs. other modalities (Non-CRT). MATERIALS AND

methodsPatients with non-metastatic cutaneous angiosarcoma diagnosed from 1998 to 2018 at two institutions were identified. In the CRT cohort, paclitaxel 80 mg/m

resultsFifty-seven patients were included: 22 CRT and 35 Non-CRT. The CRT cohort had more patients > 60 years (100% vs. 60%, p < 0.001) and tumors >5 cm (68.2% vs 54.3%,

conclusionThe use of concurrent paclitaxel CRT demonstrates promising outcomes. Given these results, we are currently evaluating the safety and efficacy of this regimen in prospective, phase 2 trial (NCT03921008).

Indexed as

AngiosarcomaChemotherapyConcurrent chemoradiationCRT, paclitaxel-based chemoradiationDC, distant controlLC, local controlNon-CRT, other modalitiesOS, overall survivalPaclitaxelPFS, progression-free survivalRadiation therapyRT, radiotherapy

Identifiers

PMID33604458
PMCPMC7876514
OpenAlexW3126373143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.