ArticleJournal of biological methods2021
Using a variant of the optomotor response as a visual defect detection assay in zebrafish.
Article in Journal of biological methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The Effects of Suspended Sediments, Dye, and Their Variation on Fish Behavior.Ecology and evolution · 2026Article
- Early life tributyltin exposure has long term physiological effects on the zebrafish (Danio rerio) visual system.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2026Article
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- Population Genomics of Premature Termination Codons in Cavefish With Substantial Trait Loss.Molecular biology and evolution · 2025Article
- Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae.International journal of molecular sciences · 2025Article
- Zebrafish larva interface: an accessible, modular platform forFrontiers in neuroscience · 2025Article
- Impact of red and blue monochromatic light on the visual system and dopamine pathways in juvenile zebrafish.BMC ophthalmology · 2024Article
- Zebrafish models of human-duplicatedbioRxiv : the preprint server for biology · 2024Article
- Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes.Scientific reports · 2024Article
- The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults.International journal of nanomedicine · 2024Article
- Behavioral effects of visual stimuli in adult zebrafish using a novel eight-tank imaging system.Frontiers in behavioral neuroscience · 2024Article
- Review
- Optimizing assays of zebrafish larvae swimming performance for drug discovery.Expert opinion on drug discovery · 2023Review
- Top2a promotes the development of social behavior via PRC2 and H3K27me3.Science advances · 2022Article
- Prolonged Hyperglycemia Causes Visual and Cognitive Deficits inInternational journal of molecular sciences · 2022Article
- Zebrafish Behavioral Assays in Toxicology.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Time dependent effects of prolonged hyperglycemia in zebrafish brain and retina.Frontiers in ophthalmology · 2022Article
- Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A.Journal of developmental biology · 2021Article
- Transient developmental exposure to tributyltin reduces optomotor responses in larval zebrafish (Danio rerio).Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a visual stimulus that can be used with both larval and adult zebrafish (Danio rerio). This protocol is a modification of a standard visual behavior analysis, the optomotor response (OMR). The OMR is often used to determine the spatial response or to detect directional visuomotor deficiencies. An OMR can be generated using a high contrast grated pattern, typically vertical bars. The spatial sensitivity is measured by detection and response to a change in grating bar width and is reported in cycles per degree (CPD). This test has been used extensively with zebrafish larvae and adults to identify visual- and/or motor-based mutations. Historically, when tested in adults, the grated pattern was presented from a vertical perspective, using a rotating cylinder around a holding tank, allowing the grating to be seen solely from the sides and front of the organism. In contrast, OMRs in zebrafish larvae are elicited using a stimulus projected below the fish. This difference in methodology means that two different experimental set-ups are required: one for adults and one for larvae. Our visual stimulus modifies the stimulation format so that a single OMR stimulus, suitable for use with both adults and larvae, is being presented underneath the fish. Analysis of visuomotor responses using this method does not require costly behavioral tracking software and, using a single behavioral paradigm, allows the observer to rapidly determine visual spatial response in both zebrafish larvae and adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.