Evidence map›Paper›PMID 33604271›Full record

ArticleAsia Pacific allergy2021

Hong Kong Anaphylaxis Consortium Consensus Statements on prescription of adrenaline autoinjectors in the acute care setting.

Philip H Li, Gilbert T Chua, Agnes S Y Leung, Yiu-Cheung Chan, Karen K L Chan, Koon-Ho Cheung, Patrick C Y Chong, Polly P K Ho, Mike Y W Kwan, Jeffrey C H Lai and 12 more

Open access · diamondAbstract read
In one paragraph

Article in Asia Pacific allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 12 institutions in 8 countries.

Philip H LiDivision of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0002-9155-9162
Gilbert T ChuaDepartment of Paediatrics & Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0003-0333-0059
Agnes S Y LeungDepartment of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0001-8249-4478
Yiu-Cheung ChanAccident & Emergency Department, United Christian Hospital, Hong Kong.
Karen K L Chan24-Hour Outpatient and Emergency Department, Gleneagles Hong Kong Hospital, Hong Kong.
Koon-Ho CheungAccident & Emergency Department, Prince of Wales Hospital, Hong Kong.
Patrick C Y ChongPrivate practice, Hong Kong.
Polly P K HoDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong.
Mike Y W KwanDepartment of Paediatrics & Adolescent Medicine, Princess Margaret Hospital, Hong Kong.
Jeffrey C H LaiAccident & Emergency Department, Tin Shui Wai Hospital, Hong Kong.
Kin-Kwai LamAccident & Emergency Department, United Christian Hospital, Hong Kong.
Tommy S K LamAccident & Emergency Department, Pok Oi Hospital, Hong Kong.
Ting-Fan LeungDepartment of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Tin-Yan LiAccident & Emergency Department, Queen Elizabeth Hospital, Hong Kong.
Jaime S Rosa DuqueDepartment of Paediatrics & Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Jerome L T SoAccident & Emergency Department, Tseung Kwan O Hospital, Hong Kong.
Kuang-An WanAccident & Emergency Department, Ruttonjee Hospital, Hong Kong.
Henry C Y WongAccident & Emergency Department, Pok Oi Hospital, Hong Kong.
Adrian Y Y WuCentre for Allergy and Asthma Care, Hong Kong.
Tak-Hong LeeAllergy Centre, Hong Kong Sanatorium and Hospital, Hong Kong.
Marco H K HoDepartment of Paediatrics & Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Axel Y C SiuAccident & Emergency Department, Ruttonjee Hospital, Hong Kong.
Queen Mary Hospital · CNChinese University of Hong Kong · CNPok Oi Hospital · HKQueen Elizabeth Hospital · CNRuttonjee Hospital · CNUnited Christian Hospital · CNENT and Allergy · USGleneagles Hospital · SGIS practice · BEPrince of Wales Hospital · CNPrincess Margaret Hospital · NZTseung Kwan O Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdrenaline autoinjectors (AAInj) facilitates early administration of adrenaline and remains the first-line treatment for anaphylaxis. However, only a minority of anaphylaxis survivors in Hong Kong are prescribed AAInj and formal guidance do not exist. International anaphylaxis guidelines have been largely based on Western studies, which may not be as relevant for non-Western populations.

objectiveTo formulate a set of consensus statements on the prescription of AAInj in Hong Kong.

methodsConsensus statements were formulated by the Hong Kong Anaphylaxis Consortium by the Delphi method. Agreement was defined as greater than or equal to 80% consensus. Subgroup analysis was performed to investigate differences between allergy and emergency medicine physicians.

resultsA total of 7 statements met criteria for consensus with good overall agreement between allergy and emergency medicine physicians. AAInj should be used as first-line treatment and prescribed for all patients at risk of anaphylaxis. This should be prescribed prior to discharge from the Accident and Emergency Department together with an immediate referral to an allergy center. The decision for prescribing AAInj should be based on the severity of previous reactions; including objective signs of respiratory involvement, objective signs of cardiovascular involvement and multiorgan involvement (regardless of severity). Patient demographics and comorbidities, specifically history of asthma or chronic obstructive pulmonary disease, should also be considered. Patients deemed eligible for AAInj should be offered avoidance advice and prescribed one AAInj while awaiting review by allergists. AAInj technique should be demonstrated by a healthcare professional or instruction video, and a return demonstration by the patient is required. The patient should also be counseled that the decision on the continued need of AAInj prescription in the long-term should be reviewed by an allergist.

conclusionConsensus statements support the prescription of AAInj by front-line physicians with subsequent allergist review when treating patients at risk of anaphylaxis in Hong Kong.

Indexed as

AdrenalineAnaphylaxisAutoinjectorConsensusConsortiumHong Kong

Identifiers

PMID33604271
PMCPMC7870372
OpenAlexW3120890722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.