ArticlePeerJ2021
Quantifying upper limb motor impairment in people with Parkinson's disease: a physiological profiling approach.
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Immersive virtual reality upper-limb exercises in people with Parkinson's disease: an observer-blinded randomised controlled trial.Journal of neuroengineering and rehabilitation · 2026Trial
- Trial
- Age-related changes in mobility assessments correlate with repetitive goal-directed arm-movement performance.BMC geriatrics · 2023Trial
- Reliability and convergent validity of the 6-minute pegboard and ring test in people with Parkinson's disease: a cross-sectional study.Acta neurologica Belgica · 2026Article
- Auditory cueing modulates motor performance and brain activity in early Parkinson's disease-a kinematic and fMRI study.NPJ Parkinson's disease · 2026Article
- Parkinson's disease functional movement battery a comprehensive test set to evaluate of motor abilities in persons with Parkinson's disease.Scientific reports · 2025Article
- Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF-κB/STAT-1 Pathway.Brain and behavior · 2025Article
- Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease.Frontiers in neuroscience · 2025Article
- Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.NPJ Parkinson's disease · 2024Article
- Feasibility of virtual low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson's disease.MethodsX · 2023Article
- Use of a physiological profile to document upper limb motor impairment in ageing and in neurological conditions.The Journal of physiology · 2023Review
- Rate control deficits during pinch grip and ankle dorsiflexion in early-stage Parkinson's disease.PloS one · 2023Article
- Virtual Reality for Motor and Cognitive Rehabilitation.Current topics in behavioral neurosciences · 2023Article
- Medication only improves limb movements while deep brain stimulation improves eye and limb movements during visually-guided reaching in Parkinson's disease.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUpper limb motor impairments, such as slowness of movement and difficulties executing sequential tasks, are common in people with Parkinson's disease (PD).
objectiveTo evaluate the validity of the upper limb Physiological Profile Assessment (PPA) as a standard clinical assessment battery in people with PD, by determining whether the tests, which encompass muscle strength, dexterity, arm stability, position sense, skin sensation and bimanual coordination can (a) distinguish people with PD from healthy controls, (b) detect differences in upper limb test domains between "off" and "on" anti-Parkinson medication states and (c) correlate with a validated measure of upper limb function.
methodsThirty-four participants with PD and 68 healthy controls completed the upper limb PPA tests within a single session.
resultsPeople with PD exhibited impaired performance across most test domains. Based on validity, reliability and feasibility, six tests (handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning) were identified as key tests for the assessment of upper limb function in people with PD.
conclusionsThe upper limb PPA provides a valid, quick and simple means of quantifying specific upper limb impairments in people with PD. These findings indicate clinical assessments should prioritise tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks in people with PD as these domains are the most commonly and significantly impaired.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.