ArticleExperimental and therapeutic medicine2021
Correlations of cardiac function with inflammation, oxidative stress and anemia in patients with uremia.
Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of Ubiquinol on Oxidized Low-Density Lipoprotein in Prediabetic Patients: A Randomized, Double-Blinded, Placebo-Controlled Study.BioMed research international · 2026Trial
- Abdominal Obesity, Hepatic Steatosis, Oxidative Stress and Diastolic Dysfunction in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Article
- Profiling oxidative stress markers and cardiovascular complications in chronic kidney disease patients supplemented with vitamin E.Archives of medical sciences. Atherosclerotic diseases · 2024Article
- Clinical outcome of intraoperative hemodialysis using a hemoconcentrator during cardiopulmonary bypass for dialysis-dependent patients.General thoracic and cardiovascular surgery · 2023Article
- Review
- Decreased cardiac output: an integrative review.Revista brasileira de enfermagem · 2023Review
- Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to analyze the associations of cardiac function with inflammatory cytokines, oxidative stress and anemia in patients with uremia. A total of 79 patients with uremia were selected, and among those, 43 cases were complicated with cardiac dysfunction (observation group) and 36 patients were not (control group). The levels of inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10], oxidative stress indicators [malondialdehyde (MDA), oxidized low-density lipoprotein (OX-LDL) and advanced oxidation protein products (AOPP)], blood routine parameters [hemoglobin (Hb), platelets (PLT), mean corpuscular volume (MCV)], and cardiac function [including cardiac output (CO), cardiac stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd)] were measured. There were no statistically significant differences in age, sex, body mass index, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol between the observation and the control group (P>0.05), but the observation group had significantly higher triglyceride levels and blood pressure, as well as longer duration of uremia compared with those in the control group (P<0.05). Furthermore, the levels of CRP, IL-6, IL-10, MDA, OX-LDL, AOPP, Hb, PLT and MCV in the observation group were significantly higher than those in the control group. In addition, regarding cardiac function, the observation group had a decreased CO, SV and LVEF and an increased LVEDd and LVESd compared with those in the control group. Furthermore, CRP (r=-0.636, P<0.01) and MDA (r=-0.705, P<0.01) were negatively correlated with LVEF, while Hb levels were positively correlated with LVEF (r=0.732, P<0.001). In conclusion, serum inflammatory cytokines, oxidative stress and the degree of anemia are associated with cardiac insufficiency in patients with uremia.
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