Development of an Electroactive Hydrogel as a Scaffold for Excitable Tissues.

Kriti Gupta, Ruchi Patel, Madara Dias, Hina Ishaque, Kristopher White, Ronke Olabisi

Abstract read

In one paragraph

Article in International journal of biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Smart Hydrogels for Tissue Regeneration.Macromolecular bioscience · 2024
Review
Electrical Stimulation in Cartilage Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kriti Gupta *Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA.

Ruchi Patel *Graduate School of Biomedical Sciences, Rutgers University, Piscataway, NJ, USA.

Madara DiasDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA.

Hina IshaqueDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA.

Kristopher WhiteDepartment of Biomedical Engineering, The Henry Samueli School of Engineering, University of California-Irvine, Irvine, CA 92697, ZOT Code 2715, USA.

Ronke OlabisiDepartment of Biomedical Engineering, The Henry Samueli School of Engineering, University of California-Irvine, Irvine, CA 92697, ZOT Code 2715, USA.ORCID https://orcid.org/0000-0003-3738-5250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many cells used in tissue engineering applications, the scaffolds upon which they are seeded do not entirely mimic their native environment, particularly in the case of excitable tissues. For instance, muscle cells experience contraction and relaxation driven by the electrical input of an action potential. Electroactive materials can also deform in response to electrical input; however, few such materials are currently suitable as cell scaffolds. We previously described the development of poly(ethyelene glycol) diacrylate-poly(acrylic acid) as an electroactive scaffold. Although the scaffold itself supported cell growth and attachment, the voltage (20 V) required to actuate these scaffolds was cytotoxic. Here, we describe the further development of our hydrogels into scaffolds capable of actuation at voltages (5 V) that were not cytotoxic to seeded cells. This study describes the critical next steps towards the first functional electroactive tissue engineering scaffold.

Identifiers

PMID33603789

DOI10.1155/2021/6669504

PMCPMC7868160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.