ArticleFrontiers in immunology2020
T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review).International journal of molecular medicine · 2026Review
- Disturbed LTB4 Metabolism in ILC2s Aggravates Ulcerative Colitis via Intercellular ATP Accumulation.Inflammation · 2026Article
- Plasticity and antigen presentation by group 3 innate lymphoid cells in colorectal cancer.Frontiers in immunology · 2026Review
- CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner.Nature communications · 2024Article
- Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy.Frontiers in immunology · 2023Review
- CD90 is not constitutively expressed in functional innate lymphoid cells.Frontiers in immunology · 2023Article
- The role of group 3 innate lymphoid cell in intestinal disease.Frontiers in immunology · 2023Review
- ILC3: a case of conflicted identity.Frontiers in immunology · 2023Review
- Organoids capture tissue-specific innate lymphoid cell development in mice and humans.Cell reports · 2022Article
- Transcription factor-driven regulation of ILC1 and ILC3.Trends in immunology · 2022Review
- Food for thought - ILC metabolism in the context of helminth infections.Mucosal immunology · 2022Review
- Innate Lymphoid Cells and Intestinal Inflammatory Disorders.International journal of molecular sciences · 2022Review
- The emerging role of group 3 innate lymphoid cells in the neonate: interaction with the maternal and neonatal microbiome.Oxford open immunology · 2021Review
- Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid CellsFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD). However, a role of T-bet-negative ILC3 in driving colitis has also been suggested in mouse models questioning T-bet as a critical factor for IBD. We report here that T-bet deficient mice had a greater cellularity of NKp46-negative ILC3 correlating with enhanced expression of RORγt and IL-7R, but independent of signaling through STAT1 or STAT4. We observed enhanced neutrophilia in the colonic lamina propria (cLP) of these animals, however, we did not detect a greater risk of T-bet-deficient mice to develop spontaneous colitis. Furthermore, by utilizing an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.