Evidence map›Paper›PMID 33603744›Full record

ReviewFrontiers in immunology2020

The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.

Matthew Clark, Charles J Kroger, Qi Ke, Roland M Tisch

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew ClarkDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Charles J KrogerDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Qi KeDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Roland M TischDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
BASIC IMMUNE MECHANISMST32AI007273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 1985 to 2020
$5.6M
Thymic and peripheral regulation of autoreactive T cells by coreceptor therapyR01AI139475 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2019 to 2023
$1.9M
Islet-Specific Tolerance Induced by T Cell Co-Receptor Therapy in Type 1 DiabetesR01DK100256 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2014 to 2018
$1.7M
The role of AIM2 in T cell-mediated autoimmunityR01AI141631 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2019 to 2022
$1.6M
Human CD8+ T Cell Tolerance by Nondepleting Humanized CD8-Specific AntibodyR21AI115752 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2015 to 2016
$433k
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI139475NIAID NIH HHS R01 AI141631NIAID NIH HHS R21 AI115752NIAID NIH HHS T32 AI007273NIDDK NIH HHS R01 DK100256
6 · The paper itself

Abstract

T cell receptor (TCR) signaling influences multiple aspects of CD4

Indexed as

Models, ImmunologicalAutoantigensAutoimmunityB7-H1 AntigenCell LineageClonal Selection, Antigen-MediatedCytokinesDiabetes Mellitus, Type 1DNA MethylationGene Expression RegulationHistone CodeHomeostasisHumansImmunologic MemoryLymphocyte ActivationProgrammed Cell Death 1 ReceptorAutoantigensB7-H1 AntigenCD274 protein, humanCytokinesPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellautoimmunitydiabetesimmunoregulationT cell differentiationT cell receptor (TCR) signaling

Identifiers

PMID33603744
PMCPMC7884625
OpenAlexW3127234869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.