Evidence map›Paper›PMID 33603730›Full record

ArticleFrontiers in immunology2020

Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1.

Gerco den Hartog, Lindsay D Butcher, Amber L Ablack, Laura A Pace, Jailal N G Ablack, Richard Xiong, Soumita Das, Thaddeus S Stappenbeck, Lars Eckmann, Peter B Ernst and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Novel HypomorphicAntioxidants & redox signaling · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Gerco den HartogDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Lindsay D ButcherDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Amber L AblackDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Laura A PaceDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Jailal N G AblackDepartment of Medicine, Division of Rheumatology, University of California San Diego, La Jolla, CA, United States.
Richard XiongDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Soumita DasDivision of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, United States.
Thaddeus S StappenbeckDivision of ImmunoBiology, Washington University, St. Louis, MO, United States.
Lars EckmannDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
Peter B ErnstDivision of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, United States.
Sheila E CroweDepartment of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, CA, United States.
University of California, San Diego · USWashington University in St. Louis · US

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
The Role of the Adenosine Receptor in Th Cell Development and FunctionR01AI079145 · NIAID · UNIVERSITY OF VIRGINIA · PI ERNST, PETER B. · 2010 to 2022
$4.7M
OXIDATIVE INJURY TO GASTRIC EPITHELIAL CELLS BY H. PYLORIR01DK061769 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CROWE, SHEILA E. · 2001 to 2015
$3.6M
NIAID NIH HHS R01 AI079145NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK061769NIDDK NIH HHS T32 DK007202NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Pathogenic intestinal bacteria lead to significant disease in humans. Here we investigated the role of the multifunctional protein, Apurinic/apyrimidinic endonuclease 1 (APE1), in regulating the internalization of bacteria into the intestinal epithelium. Intestinal tumor-cell lines and primary human epithelial cells were infected with

Indexed as

ColonEpithelial CellsEscherichia coli InfectionsIntestinal MucosaSalmonella InfectionsDNA-(Apurinic or Apyrimidinic Site) LyaseEscherichia coliHT29 CellsHumansrac1 GTP-Binding ProteinSalmonella typhimuriumAPEX1 protein, humanDNA-(Apurinic or Apyrimidinic Site) Lyaserac1 GTP-Binding ProteinRAC1 protein, humanAIEC LF82 strainapurinic/apyrimidinic endonuclease 1internalizationintestinal epithelial barrierinvasionRac1Salmonella Typhimurium

Identifiers

PMID33603730
PMCPMC7884313
OpenAlexW3129132615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.