Evidence map›Paper›PMID 33603718›Full record

ReviewFrontiers in microbiology2020

Probiotics and MicroRNA: Their Roles in the Host-Microbe Interactions.

Ying Zhao, Yan Zeng, Dong Zeng, Hesong Wang, Mengjia Zhou, Ning Sun, Jinge Xin, Abdul Khalique, Danish Sharafat Rajput, Kangcheng Pan and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Lactobacilli and gut pH: features of correlation in model experiments.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Neuroprotective Effects ofInternational journal of molecular sciences · 2023
    Article
  15. Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ying ZhaoAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Yan ZengAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Dong ZengAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Hesong WangGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Mengjia ZhouSichuan Academy of Animal Sciences, Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu, China.
Ning SunAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Jinge XinAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Abdul KhaliqueAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Danish Sharafat RajputAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Kangcheng PanAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Gang ShuAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Bo JingAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Xueqin NiAnimal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Sichuan Agricultural University · CNSichuan Animal Science Academy · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis - the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host-microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host-microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics-miRNA-host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.

Indexed as

gut microbiotahomeostasishost–microbe interactionsmicroRNAprobiotics

Identifiers

PMID33603718
PMCPMC7885260
OpenAlexW3120976967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.