ArticleRisk management and healthcare policy2021
Incidence of Co-Trimoxazole-Induced Hyperkalemia in a Tertiary Care Hospital.
Article in Risk management and healthcare policy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Arbor Accidents and Asteroids.Clinical case reports · 2026Article
- Hyperkalemic effect of drug-drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study.Journal of pharmaceutical health care and sciences · 2024Article
- A Retrospective Analysis of Patients Presenting with Acute Hyperkalemia in an Emergency Care Setting.Risk management and healthcare policy · 2024Article
- Prevalence and management of hyperkalemia in chronic kidney disease and heart failure patients in the Gulf Cooperation Council (GCC).Journal of clinical hypertension (Greenwich, Conn.) · 2023Review
- Cotrimoxazole-induced hyperkalemia in renal transplant patient-Case report.Clinical case reports · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCo-trimoxazole is a broad-spectrum antibiotic associated with hyperkalemia.
objectiveTo determine the incidence of hyperkalemia and its risk factors in patients receiving co-trimoxazole. MATERIALS AND
methodsA retrospective observational study involving all patients who received co-trimoxazole between 1 January 2012 and 1 January 2013 was conducted. Subjects were identified through a list generated from a computerized pharmacy system. The patients' demographic and clinical characteristics were retrieved from electronic medical records. Data were analyzed using univariate and multivariate logistic regression.
resultsOne hundred sixty-one patients fulfilled the eligibility criteria. Of these, 46 (28.6%) experienced hyperkalemia. Around 35 (76%) of the patients who experienced hyperkalemia received co-administered medications that might induce hyperkalemia. The co-administration of co-trimoxazole with other medications that may induce hyperkalemia was found to be associated with higher incidence of hyperkalemia when compared to co-trimoxazole administration alone [adjusted OR 3.2, 95% CI (1.4-7.3), p=0.005]. Additionally, age > 60 years was associated with an increased risk of hyperkalemia when compared to younger age group 18-39 years [adjusted OR 6.5, 95% CI (2.1-19.7); p=0.001].
conclusionCo-trimoxazole use is associated with high incidence of hyperkalemia, especially among older patients and those receiving it in combination with other medications that might contribute to hyperkalemia development such as calcineurin inhibitors and β-blockers.
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