Evidence map›Paper›PMID 33603409›Full record

ReviewJournal of asthma and allergy2021

Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps.

Claus Bachert, Neil Bhattacharyya, Martin Desrosiers, Asif H Khan

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of asthma and allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 156 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 4 pooled it
30.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06070311 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Thymoquinone and Olive Oil on Wound Healing After Endoscopic Sinus Surgery in Patients With Nasal Polyposis

TypeinterventionalSponsorAssiut UniversityRan2023 to 2025Enrolled50ConditionsNasal Polyps, Chronic SinusitisArmsThymoquinone (0.5%) and Olive oil ointment
NCT07616609 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Placebo-Controlled, Double-Blinded Trial of Preoperative Stapokibart With Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps

TypeinterventionalSponsorBeijing Tongren HospitalRan2026 to 2028Enrolled48ConditionsChronic Rhinosinusitis With Nasal Polyps (CRSwNP)ArmsStapokibart, Matched placebo
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 4 syntheses or guidelines pooled it, 253 citations in OpenAlex.

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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 5 countries.

Claus BachertUpper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
Neil BhattacharyyaDepartment of Otolaryngology, Harvard Medical School, Boston, MA, USA.
Martin DesrosiersCentre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID 0000-0003-3774-2959
Asif H KhanUpper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
Centre Hospitalier de l’Université de Montréal · CAHarvard University · USKarolinska Institutet · SESanofi (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology.

Indexed as

disease severityhealthcare economicsparanasal sinus diseasequality of life

Identifiers

PMID33603409
PMCPMC7886239
OpenAlexW3126598211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.