Evidence map›Paper›PMID 33603383›Full record

ArticleNeuropsychiatric disease and treatment2021

Valproate Reverses Mania-Like Behavior of

Shasha Liu, Jinxue Wei, Rongjun Ni, Tianhao Gao, Peiyan Ni, Liansheng Zhao, Xiyu Duan, Xiaohong Ma, Pak C Sham, Tao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. The engagement of autophagy in maniac disease.CNS neuroscience & therapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shasha LiuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People's Republic of China.
Jinxue WeiPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Rongjun NiPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Tianhao GaoBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People's Republic of China.
Peiyan NiPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Liansheng ZhaoPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0002-3008-5135
Xiyu DuanPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Xiaohong MaPsychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0003-2627-9946
Pak C ShamDepartment of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, People's Republic of China.
Tao LiBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People's Republic of China.
Sichuan University · CNCapital Medical University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMice with a deletion at exon 19 of the circadian locomotor output cycles Kaput gene (

methodsWildtype (WT) and

resultsVPA can reverse hyperactivity, lower level of anxiety-like and depression-like behaviors of the

conclusionOur results indicated that chronic VPA treatment can reverse the mania-like behaviors of the

Indexed as

bipolar disorderClockdelta19 mousemania-like behaviorneurotransmittervalproate

Identifiers

PMID33603383
PMCPMC7884953
OpenAlexW3128119597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.