Evidence map›Paper›PMID 33603357›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Study.

Clarus Leung, Jean Bourbeau, Don D Sin, Shawn D Aaron, J Mark FitzGerald, François Maltais, Darcy D Marciniuk, Denis O'Donnell, Paul Hernandez, Kenneth R Chapman and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623709 (Health Outcomes Following Treatment With Continuous Positive Airway Pressure or Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease and a Sleep Related Breathing Disorder), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623709 terminatednot on this map

Health Outcomes Following Treatment With Continuous Positive Airway Pressure or Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease and a Sleep Related Breathing Disorder

TypeobservationalSponsorUniversity of AlbertaRan2022 to 2024Enrolled11ConditionsChronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, HypoventilationArmsPositive airway pressure with continuous positive airway pressure or noninvasive ventilation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. User-Centered Design of an Electronic COPD Patient Questionnaire for Clinical Decision Support.International journal of chronic obstructive pulmonary disease · 2026
    Article
  6. Article
  7. Article
  8. COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era.International journal of chronic obstructive pulmonary disease · 2025
    Article
  9. Article
  10. Article
  11. A Multi-Specialty Delphi Consensus on Assessing and Managing Cardiopulmonary Risk in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2024
    Article
  12. Article
  13. Observational
  14. Article
  15. Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors.International journal of environmental research and public health · 2023
    Review
  16. Physical Activity and Symptom Burden in COPD: The Canadian Obstructive Lung Disease Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Clarus LeungCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-3515-7537
Jean BourbeauResearch Institute McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
Don D SinCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0756-6643
Shawn D AaronThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
J Mark FitzGeraldDepartment of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.
François MaltaisInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0002-6809-4651
Darcy D MarciniukRespiratory Research Centre, University of Saskatchewan, Saskatoon, Canada.
Denis O'DonnellDepartment of Medicine, Queen's University, Kingston, Canada.
Paul HernandezDepartment of Medicine, Dalhousie University, Halifax, Canada.
Kenneth R ChapmanToronto General Hospital Research Institute, University of Toronto, Toronto, Canada.ORCID 0000-0002-2498-9859
Brandie WalkerDepartment of Medicine, University of Calgary (BW), Alberta, Canada.
Jeremy D RoadDepartment of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.
Liyun ZhengCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.
Carl ZouCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.
James C HoggCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.
Wan C TanCentre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-9289-3595
CanCOLD Collaborative Research Group
University of British Columbia · CADalhousie University · CAInstitut universitaire de cardiologie et de pneumologie de Québec · CAMcGill University Health Centre · CAQueen's University · CAUniversity of Calgary · CAUniversity of Ottawa · CAUniversity of Saskatchewan · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the spirometric-based prevalence of COPD across different regions in Canada and to evaluate the site heterogeneity of risk factors. PATIENTS AND

methodsIn this cross-sectional, population-based study, random samples of non-institutionalized adults aged ≥40 years were generated by random digit dialling. Participants answered an interviewer-administered questionnaire and performed spirometry before and after bronchodilator administration. COPD was defined as post-bronchodilator FEV

resultsOut of 5176 (95%) participants, 4893 (47% male with mean age 56.6 years (95% confidence interval, 56.0-57.2)) had spirometry that satisfied ATS criteria. The population prevalence of COPD was 16.2% (95% CI, 14.5-17.8) by FR and 11.2% (95% CI, 9.7-12.6) by LLN. Male predominance in prevalence was shown by FR but not by LLN criteria. Patient characteristics associated with an increased risk of COPD included: age (OR 1.56; 95% CI 1.33-1.84); history of physician-diagnosed asthma (OR 3.30; 95% CI 2.42-4.49); and childhood hospitalization for respiratory illness (OR 1.81; 95% CI 1.17-2.80). In terms of smoking-related risk factors, current smoking status had the highest odds ratio (OR 3.49; 95% CI 2.55-4.80). Variance in prevalence among sites was significantly reduced by adjusting for risk factors in Tau

conclusionThis study reports the population prevalence of COPD in nine urban cities which collectively represent the majority of the Canadian population and demonstrates that heterogeneity in prevalence among sites is substantially explained by variation in associated risk factors for COPD.

Indexed as

Pulmonary Disease, Chronic ObstructiveAdultCanadaChildCross-Sectional StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedPrevalenceRisk FactorsSpirometryVital CapacityCOPDheterogeneityprevalence

Identifiers

PMID33603357
PMCPMC7886112
OpenAlexW3126650522

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.