Evidence map›Paper›PMID 33603350›Full record

ArticleNanotechnology, science and applications2021

Lipid Nanosystems and Serum Protein as Biomimetic Interfaces: Predicting the Biodistribution of a Caffeic Acid-Based Antioxidant.

Eduarda Fernandes, Sofia Benfeito, Fernando Cagide, Hugo Gonçalves, Sigrid Bernstorff, Jana B Nieder, M Elisabete Cd Real Oliveira, Fernanda Borges, Marlene Lúcio

Open access · goldAbstract read
In one paragraph

Article in Nanotechnology, science and applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Nano-biotechnology in tumour and cancerous disease: A perspective review.Journal of cellular and molecular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Eduarda FernandesDepartamento de Física da Universidade do Minho, CF-UM-UP, Centro de Física das Universidades do Minho e Porto, Campus de Gualtar, Braga, 4710-057, Portugal.ORCID 0000-0002-0870-039X
Sofia BenfeitoCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.ORCID 0000-0001-9645-8152
Fernando CagideCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.ORCID 0000-0001-9410-6874
Hugo GonçalvesParalab, SA, Valbom, 4420-392, Portugal.ORCID 0000-0002-1357-1764
Sigrid BernstorffElettra-Sincrotrone Trieste S. C.p.A.,, Basovizza, Trieste, I-34149, Italy.ORCID 0000-0001-6451-5159
Jana B NiederUltrafast Bio- and Nanophotonics Group, INL - International Iberian Nanotechnology Laboratory, Braga, Portugal.ORCID 0000-0002-4973-1889
M Elisabete Cd Real OliveiraDepartamento de Física da Universidade do Minho, CF-UM-UP, Centro de Física das Universidades do Minho e Porto, Campus de Gualtar, Braga, 4710-057, Portugal.ORCID 0000-0002-9728-8172
Fernanda BorgesCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.ORCID 0000-0003-1050-2402
Marlene LúcioDepartamento de Física da Universidade do Minho, CF-UM-UP, Centro de Física das Universidades do Minho e Porto, Campus de Gualtar, Braga, 4710-057, Portugal.ORCID 0000-0003-2593-1672
Universidade do Porto · PTInternational Iberian Nanotechnology Laboratory · PTUniversity of Minho · PTElettra-Sincrotrone Trieste S.C.p.A. · ITParalab (Portugal) · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAntiOxCIN

methodsIntestinal and cell membrane permeation of AntiOxCIN RESULTS AND DISCUSSION: We found that AntiOxCIN

conclusionDrug interactions with biological interfaces may be evaluated using membrane model systems and serum proteins. This knowledge is important for the characterization of drug partitioning, positioning and orientation of drugs in membranes, their effect on membrane biophysical properties and the study of serum protein binding. The analysis of these interactions makes it possible to collect valuable knowledge on the transport, distribution, accumulation and, eventually, therapeutic impact of drugs which may aid the drug development process.

Indexed as

biomimetic modelsbiophysical profilingblood–brain barrier permeabilitydrug distributiondrug–membrane interactionsmall and wide-angle X-ray diffraction

Identifiers

PMID33603350
PMCPMC7882595
OpenAlexW3129004143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.