Evidence map›Paper›PMID 33603305›Full record

ReviewIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2021

Drug Interactions between Antimicrobial and Immunosuppressive Agents in Solid Organ Transplant Recipients.

Vikas Bhagat, Rahul A Pandit, Shwetha Ambapurkar, Manju Sengar, Atul P Kulkarni

Open access · diamondAbstract readReview
In one paragraph

Review in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Hepatic involvement in major respiratory viral infections.Clinical and experimental hepatology · 2025
    Review
  6. Review
  7. Clinically important pharmacokinetic drug-drug interactions with antibacterial agents.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  8. Article
  9. Article
  10. Physical Exercise After Solid Organ Transplantation: A Cautionary Tale.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  11. Article
  12. Outpatient and peri-operative antibiotic stewardship in solid organ transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Vikas BhagatDepartment of Critical Care Medicine, Aster Hospital, Dubai, UAE.
Rahul A PanditFortis Hospital, Mumbai, Maharashtra, India.
Shwetha AmbapurkarDepartment of Pharmacology, Fortis Hospital, Mumbai, Maharashtra, India.
Manju SengarDepartment of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Atul P KulkarniDivision of Critical Care Medicine, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Dubai Hospital · AEFortis Hospital · INHomi Bhabha National Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of allogeneic solid organ and bone marrow transplants is increasing all over the world. To prevent transplant rejection and treat acute rejection of transplant, immunosuppressant drugs are used. The outcomes of solid organ transplants have dramatically improved over last 30 years, due to availability of multiple immunosuppressive agents, with varied mechanisms of action. The use of intense immunosuppression makes the individual having undergone solid organ transplant at the risk of several serious infections, which may prove fatal. To prevent and treat these infections (when they occur), patients are often given antimicrobial prophylaxis and therapy. The use of antimicrobials can interfere with the metabolism of the immunosuppressants, and may put the patient at risk of developing severe adverse effects due to unwanted increase or decrease in the serum levels of immunosuppressive agents. Knowledge of these interactions is essential for successful management of solid organ transplant patients. We therefore decided to review the literature and present the interactions that commonly occur between these two life-saving groups of drugs.

Indexed as

AntimicrobialsCalcineurin inhibitorsCorticosteroidsDrug–drug interactionImmunosuppressantsIntravenous immunoglobulinMonoclonal antibodiesmTOR inhibitorsSolid organ transplant

Identifiers

PMID33603305
PMCPMC7874296
OpenAlexW3118480345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.