ArticleNature chemical biology2021
Optical control of fast and processive engineered myosins in vitro and in living cells.
Article in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Spatial Activity Patterning and Topological Defect Transport in Acoustically Energized Active Liquid Crystals.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
- Beyond the Single Molecule: Multiplexed Methods in Force Spectroscopy.Annual review of biophysics · 2026Review
- Light-induced assembly and repeatable actuation in CaNature communications · 2026Article
- Elucidating chiral myosin-induced actin dynamics: From single-filament behavior to collective structures.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Engineering filamentous myosins for optical control of contractility.bioRxiv : the preprint server for biology · 2025Article
- Synthetic Active Liquid Crystals Powered by Acoustic Waves.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Motor crosslinking augments elasticity in active nematics.Soft matter · 2024Article
- Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.Nature communications · 2024Article
- Unraveling the fastest myosin: Discovery history and structure-function relationships of algaeBiophysics and physicobiology · 2024Review
- Spontaneous flows and quantum analogies in heterogeneous active nematic films.Communications physics · 2024Article
- Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.ACS nano · 2023Article
- A unified model for the dynamics of ATP-independent ultrafast contraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- LILAC: enhanced actin imaging with an optogenetic Lifeact.Nature methods · 2023Article
- Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.Nature communications · 2022Article
- Discovery of ultrafast myosin, its amino acid sequence, and structural features.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Machine learning active-nematic hydrodynamics.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Japan-US symposium on cytoskeletal motor proteins and their associated proteins.Biophysics and physicobiology · 2021Article
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Authors and funding
16 authors.
Funding
Abstract
Precision tools for spatiotemporal control of cytoskeletal motor function are needed to dissect fundamental biological processes ranging from intracellular transport to cell migration and division. Direct optical control of motor speed and direction is one promising approach, but it remains a challenge to engineer controllable motors with desirable properties such as the speed and processivity required for transport applications in living cells. Here, we develop engineered myosin motors that combine large optical modulation depths with high velocities, and create processive myosin motors with optically controllable directionality. We characterize the performance of the motors using in vitro motility assays, single-molecule tracking and live-cell imaging. Bidirectional processive motors move efficiently toward the tips of cellular protrusions in the presence of blue light, and can transport molecular cargo in cells. Robust gearshifting myosins will further enable programmable transport in contexts ranging from in vitro active matter reconstitutions to microfabricated systems that harness molecular propulsion.
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Registered trials
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