ArticleThe ISME journal2021
Host genotype and genetic diversity shape the evolution of a novel bacterial infection.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
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- Comparative genomics of Fusarium oxysporum f. sp. albedinis reveals the effector repertoire and molecular arsenal for date palm infection.BMC plant biology · 2026Article
- Genetic diversity of iron acquisition systems of Staphylococcus aureus associated with bovine mastitis.Folia microbiologica · 2026Article
- Experimental evolution in an era of molecular manipulation.Nature reviews. Genetics · 2026Review
- First genetic characterisation and phylogenetic analysis of Trichomonadida from Gallus gallus domesticus (Aves: Phasianidae) and its nematode parasite Heterakis gallinarum (Ascaridida: Heterakidae) in Tunisia.Folia parasitologica · 2025Article
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- Mutations in the signal peptide of effector gene Pi04314 contribute to the adaptive evolution of the Phytophthora infestans.BMC ecology and evolution · 2025Article
- Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis.The ISME journal · 2025Article
- Impact ofCurrent research in microbial sciences · 2025Article
- Distinct virulence of the microsporidian parasite in honey bees competing habitat.Frontiers in cellular and infection microbiology · 2025Article
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen.Nature communications · 2024Article
- Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence.Current biology : CB · 2024Article
- Article
- Intrahost evolution of the gut microbiota.Nature reviews. Microbiology · 2023Review
- Microbes are potential key players in the evolution of life histories and aging inEcology and evolution · 2023Article
- Multi-Host PathogenAntibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pathogens continue to emerge from increased contact with novel host species. Whilst these hosts can represent distinct environments for pathogens, the impacts of host genetic background on how a pathogen evolves post-emergence are unclear. In a novel interaction, we experimentally evolved a pathogen (Staphylococcus aureus) in populations of wild nematodes (Caenorhabditis elegans) to test whether host genotype and genetic diversity affect pathogen evolution. After ten rounds of selection, we found that pathogen virulence evolved to vary across host genotypes, with differences in host metal ion acquisition detected as a possible driver of increased host exploitation. Diverse host populations selected for the highest levels of pathogen virulence, but infectivity was constrained, unlike in host monocultures. We hypothesise that population heterogeneity might pool together individuals that contribute disproportionately to the spread of infection or to enhanced virulence. The genomes of evolved populations were sequenced, and it was revealed that pathogens selected in distantly-related host genotypes diverged more than those in closely-related host genotypes. S. aureus nevertheless maintained a broad host range. Our study provides unique empirical insight into the evolutionary dynamics that could occur in other novel infections of wildlife and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.