ArticleThe ISME journal2021
Lifestyle of sponge symbiont phages by host prediction and correlative microscopy.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Insights Gained by High-throughput Chromosome Conformation Capture (Hi-C) into the Viral Modulation of Methane Production in Anaerobic Digestion.Environmental science & technology · 2026Article
- Functional Genomic Characteristics of Marine Sponge-AssociatedMicroorganisms · 2025Article
- Genomic characterisation of Actinospongicola halichondriae gen. nov., sp. nov., the first sponge-derived cultivated representative of a new genus within the class Acidimicrobiia.Antonie van Leeuwenhoek · 2025Article
- Cyanophage Infections in a Sponge Intracellular Cyanobacterial Symbiont.Environmental microbiology · 2025Article
- Novel viruses of Haloquadratum walsbyi expand the known archaeal virosphere of hypersaline environments.The ISME journal · 2025Article
- Survival strategies for the microbiome in a vent-dwelling glass sponge from the middle Okinawa Trough.Frontiers in microbiology · 2025Article
- Microbiome profiling and Actinomycetes isolation from tropical marine sponges.AIMS microbiology · 2025Article
- Phage-induced disturbance of a marine sponge microbiome.Environmental microbiome · 2024Article
- Biofilms in modern CaCOScientific reports · 2024Article
- Viral Communities Contribute More to the Lysis of Antibiotic-Resistant Bacteria than the Transduction of Antibiotic Resistance Genes in Anaerobic Digestion Revealed by Metagenomics.Environmental science & technology · 2024Article
- Spatio-functional organization in virocells of small uncultivated archaea from the deep biosphere.The ISME journal · 2023Article
- Benzo[a]pyrene stress impacts adaptive strategies and ecological functions of earthworm intestinal viromes.The ISME journal · 2023Article
- Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere.PLoS biology · 2023Article
- Viral Community Structure and Potential Functions in the Dried-Out Aral Sea Basin Change along a Desiccation Gradient.mSystems · 2023Article
- Phage Therapy in Germany-Update 2023.Viruses · 2023Article
- Detection of specific uncultured bacteriophages by fluorescence in situ hybridisation in pig microbiome.PloS one · 2023Article
- Genome-centric view of the microbiome in a new deep-sea glass sponge speciesFrontiers in microbiology · 2023Article
- How It All Begins: Bacterial Factors Mediating the Colonization of Invertebrate Hosts by Beneficial Symbionts.Microbiology and molecular biology reviews : MMBR · 2022Review
- Comparative genome analysis of Vagococcus fluvialis reveals abundance of mobile genetic elements in sponge-isolated strains.BMC genomics · 2022Article
- Symbiont transmission in marine sponges: reproduction, development, and metamorphosis.BMC biology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages (phages) are ubiquitous elements in nature, but their ecology and role in animals remains little understood. Sponges represent the oldest known extant animal-microbe symbiosis and are associated with dense and diverse microbial consortia. Here we investigate the tripartite interaction between phages, bacterial symbionts, and the sponge host. We combined imaging and bioinformatics to tackle important questions on who the phage hosts are and what the replication mode and spatial distribution within the animal is. This approach led to the discovery of distinct phage-microbe infection networks in sponge versus seawater microbiomes. A new correlative in situ imaging approach ('PhageFISH-CLEM') localised phages within bacterial symbiont cells, but also within phagocytotically active sponge cells. We postulate that the phagocytosis of free virions by sponge cells modulates phage-bacteria ratios and ultimately controls infection dynamics. Prediction of phage replication strategies indicated a distinct pattern, where lysogeny dominates the sponge microbiome, likely fostered by sponge host-mediated virion clearance, while lysis dominates in seawater. Collectively, this work provides new insights into phage ecology within sponges, highlighting the importance of tripartite animal-phage-bacterium interplay in holobiont functioning. We anticipate that our imaging approach will be instrumental to further understanding of viral distribution and cellular association in animal hosts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.