Evidence map›Paper›PMID 33603103›Full record

ArticleScientific reports2021

Interrupted time series study found mixed effects of the impact of the Bavarian smoke-free legislation on pregnancy outcomes.

Stephanie Polus, Jacob Burns, Sabine Hoffmann, Tim Mathes, Ulrich Mansmann, Jasper V Been, Nicholas Lack, Daniela Koller, Werner Maier, Eva A Rehfuess

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Stephanie PolusInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany. polus@ibe.med.uni-muenchen.de.
Jacob BurnsInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany.
Sabine HoffmannInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany.
Tim MathesInstitute for Research in Operative Medicine, Faculty of Health, School of Medicine, Witten/Herdecke University, Cologne, Germany.
Ulrich MansmannInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany.
Jasper V BeenDivision of Neonatology, Department of Paediatrics, Department of Obstetrics and Gynaecology, Department of Public Health, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Nicholas LackGerman Bavarian Quality Assurance Institute for Medical Care, Munich, Germany.
Daniela KollerInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany.
Werner MaierInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Eva A RehfuessInstitute for Medical Information Processing, Biometry, and Epidemiology - IBE, LMU Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEZimmer Biomet (Germany) · DEErasmus MC - Sophia Children’s Hospital · NLHelmholtz Zentrum München · DEInstitute for Research Information and Quality Assurance · DEWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2007 the German government passed smoke-free legislation, leaving the details of implementation to the individual federal states. In January 2008 Bavaria implemented one of the strictest laws in Germany. We investigated its impact on pregnancy outcomes and applied an interrupted time series (ITS) study design to assess any changes in preterm birth, small for gestational age (primary outcomes), and low birth weight, stillbirth and very preterm birth. We included 1,236,992 singleton births, comprising 83,691 preterm births and 112,143 small for gestational age newborns. For most outcomes we observed unclear effects. For very preterm births, we found an immediate drop of 10.4% (95%CI - 15.8, - 4.6%; p = 0.0006) and a gradual decrease of 0.5% (95%CI - 0.7, - 0.2%, p = 0.0010) after implementation of the legislation. The majority of subgroup and sensitivity analyses confirm these results. Although we found no statistically significant effect of the Bavarian smoke-free legislation on most pregnancy outcomes, a substantial decrease in very preterm births was observed. We cannot rule out that despite our rigorous methods and robustness checks, design-inherent limitations of the ITS study as well as country-specific factors, such as the ambivalent German policy context have influenced our estimation of the effects of the legislation.

Indexed as

AdultFemaleGermanyHumansInfant, Low Birth WeightInfant, PrematureInfant, Small for Gestational AgeInterrupted Time Series AnalysisPregnancyPregnancy OutcomePremature BirthRisk FactorsSmoke-Free PolicyStillbirthTobacco Smoke PollutionYoung AdultTobacco Smoke Pollution

Identifiers

PMID33603103
PMCPMC7892567
OpenAlexW3132088178

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.