Evidence map›Paper›PMID 33603082›Full record

ArticleScientific reports2021

Potential impact of a nonavalent anti HPV vaccine in Italian men with and without clinical manifestations.

Liana Bosco, Nicola Serra, Teresa Fasciana, Daniela Pistoia, Marco Vella, Leonardo Di Gregorio, Rosaria Schillaci, Antonino Perino, Gloria Calagna, Alberto Firenze and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  10. Article
  11. Review
  12. Human Papillomavirus and Male Infertility: What Do We Know?International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Liana BoscoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, Palermo, Italy.
Nicola SerraDepartment of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, Italy.
Teresa FascianaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE) "G. D'Alessandro", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy.
Daniela PistoiaUOC of Microbiology, Virology and Parasitology, Polyclinic Hospital, Palermo, Italy.
Marco VellaSection of Urology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Leonardo Di GregorioUOC of Urology and Extracorporeal Lithotripsy, Polyclinic Hospital, Palermo, Italy.
Rosaria SchillaciDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE) "G. D'Alessandro", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy.
Antonino PerinoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE) "G. D'Alessandro", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy.
Gloria CalagnaVilla Sofia Cervello Hospital, University of Palermo, Palermo, Italy.
Alberto FirenzeDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE) "G. D'Alessandro", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy.
Giuseppina CapraDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE) "G. D'Alessandro", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy. giuseppina.capra@unipa.it.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papilloma virus infection (HPV) is the most common sexually transmitted disease. Little is known about male infection. Nonavalent vaccine against types 6/11/16/18/31/33/45/52/58 was approved and neutral gender immunization programs have been proposed. This study evaluates the potential impact of nonavalent vaccine compared to quadrivalent in male living in Sicily (Italy). 58.7% of samples were HPV positive and forty-four types of HPV were identified. A significant higher estimated coverage of nonavalent vaccine than quadrivalent was observed (64.3% vs. 45.8%), with absolute and relative additional impact of 20.1% and 47.2%, respectively. Low impact of the vaccine were calculated as the empirical probability of HPV genotypes 6/11/16/18/31/33/45/52/58 alone or in combination; the high impact as empirical probability of HPV6/11/16/18/31/33/45/52/58 genotypes alone or in association with other genotypes. The potential impact of the nonavalent vaccine vs quadrivalent was significant for low and high impact (29.7% > 18:8%; 34:6% > 26.6%, respectively). Particularly, in men with lesions and risky sexual contact was significant only for low impact (35.5% > 29.7%; 31.4% > 19.7%, respectively). In partners with positive females was significant for low impact (26.3% > 15.1%) and high impact (33.7% > 23.2%). Nonavalent vaccine offers broader protection in men with HPV positive partners, who would have a potential role in the transmission of the infection.

Indexed as

AdultAgedCase-Control StudiesHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18HumansMaleMiddle AgedPapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesSicilyYoung AdultHuman Papillomavirus Recombinant Vaccine nonavalentHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18Papillomavirus Vaccines

Identifiers

PMID33603082
PMCPMC7892856
OpenAlexW3130915785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.