Evidence map›Paper›PMID 33603079›Full record

ArticleScientific reports2021

Association between EBV serological patterns and lymphocytic profile of SjS patients support a virally triggered autoimmune epithelitis.

Filipe Barcelos, Catarina Martins, Ricardo Monteiro, Joana Cardigos, Tiziano Prussiani, Miguel Sítima, Nuno Alves, José Vaz-Patto, Jaime Cunha-Branco, Luís-Miguel Borrego

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Sex-dependent mechanisms in rheumatic diseases.Nature reviews. Rheumatology · 2026
    Review
  2. The immunogenicity and safety of adenoviral-based vaccines.Current opinion in allergy and clinical immunology · 2026
    Review
  3. Article
  4. Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Viruses · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Filipe BarcelosCHRC, Comprehensive Health Research Centre, Lisbon, Portugal. fduartebarcelos@gmail.com.ORCID http://orcid.org/0000-0002-3764-0808
Catarina MartinsCHRC, Comprehensive Health Research Centre, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-0353-0421
Ricardo MonteiroCHRC, Comprehensive Health Research Centre, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-7586-5290
Joana CardigosDepartment of Ophthalmology, Centro Hospitalar de Lisboa Central, Hospital de Santo António Dos Capuchos, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-9053-0720
Tiziano PrussianiCEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056, Lisbon, Portugal.
Miguel SítimaCEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-7862-3924
Nuno AlvesDepartment of Ophthalmology, Centro Hospitalar de Lisboa Central, Hospital de Santo António Dos Capuchos, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-3301-1032
José Vaz-PattoDepartment of Rheumatology, Instituto Português de Reumatologia, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-2686-4742
Jaime Cunha-BrancoCHRC, Comprehensive Health Research Centre, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-7024-4375
Luís-Miguel BorregoCHRC, Comprehensive Health Research Centre, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-4708-438X
Universidade Nova de Lisboa · PTUnidade Local de Saúde de São José · PTHospital da Luz · PTHospital de Egas Moniz · PTInstituto Português de Malacologia · PTVodafone (Portugal) · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets in SjS, including as controls Rheumatoid arthritis patients (RA) and healthy participants (HC). SjS patients presented decreased CXCR5

Indexed as

Herpesvirus 4, HumanAutoimmune DiseasesB-Lymphocyte SubsetsCase-Control StudiesEncephalitisEpstein-Barr Virus InfectionsFemaleFlow CytometryHumansSjogren's SyndromeT-Lymphocyte Subsets

Identifiers

PMID33603079
PMCPMC7893064
OpenAlexW3129258063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.