Evidence map›Paper›PMID 33603036›Full record

ArticleScientific reports2021

Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children.

Mary Prunicki, Nicholas Cauwenberghs, Justin Lee, Xiaoying Zhou, Hesam Movassagh, Elizabeth Noth, Fred Lurmann, S Katharine Hammond, John R Balmes, Manisha Desai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Pre- and postnatal exposure to PMEnvironmental research · 2026
    Article
  5. Review
  6. Article
  7. Climate informed precision health.Frontiers in public health · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mary PrunickiSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, 94305, USA.
Nicholas CauwenberghsDepartment of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Justin LeeSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, 94305, USA.
Xiaoying ZhouSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, 94305, USA.
Hesam MovassaghSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, 94305, USA.
Elizabeth NothSchool of Public Health, University of California, Berkeley, Berkeley, CA, 94720, USA.
Fred LurmannSonoma Technology, Inc., Petaluma, CA, 94954, USA.
S Katharine HammondSchool of Public Health, University of California, Berkeley, Berkeley, CA, 94720, USA.
John R BalmesSchool of Public Health, University of California, Berkeley, Berkeley, CA, 94720, USA.
Manisha DesaiQuantitative Sciences Unit, Stanford University, Stanford, CA, 94305, USA.
Joseph C WuDepartment of Medicine, Stanford University, Stanford, CA, 94305, USA.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, 94305, USA. knadeau@stanford.edu.
Stanford University · USUniversity of California, Berkeley · USKU Leuven · BESonoma Technology (United States) · USUniversity of California, San Francisco · US

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
CHAPS Cohort MaintenanceR24ES030888 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HOLLAND, NINA T · 2020 to 2025
$1.9M
NIEHS NIH HHS R24 ES030888NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

Ambient air pollution exposure is associated with cardiovascular dysregulation and immune system alterations, yet no study has investigated both simultaneously in children. Understanding the multifaceted impacts may provide early clues for clinical intervention prior to actual disease presentation. We therefore determined the associations between exposure to multiple air pollutants and both immunological outcomes (methylation and protein expression of immune cell types associated with immune regulation) and cardiovascular outcomes (blood pressure) in a cohort of school-aged children (6-8 years; n = 221) living in a city with known elevated pollution levels. Exposure to fine particular matter (PM

Indexed as

Air PollutionBlood PressureCaliforniaCarbon MonoxideChildCpG IslandsDNA MethylationFemaleForkhead Transcription FactorsHumansInhalation ExposureInterferon-gammaInterleukin-10Interleukin-4MaleOzoneCarbon MonoxideForkhead Transcription FactorsFOXP3 protein, humanIL10 protein, humanIL4 protein, humanInterferon-gammaInterleukin-10Interleukin-4OzoneParticulate Matter

Identifiers

PMID33603036
PMCPMC7893154
OpenAlexW3132068555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.