Evidence map›Paper›PMID 33603035›Full record

ArticleScientific reports2021

Photoacoustic monitoring of oxygenation changes induced by therapeutic ultrasound in murine hepatocellular carcinoma.

Mrigendra B Karmacharya, Laith R Sultan, Chandra M Sehgal

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mrigendra B Karmacharya *Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA.
Laith R Sultan *Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA.
Chandra M SehgalDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA. Chandra.Sehgal@uphs.upenn.edu.
University of Pennsylvania · US

Funding

Antivascular ultrasound therapy of primary liver neoplasiaR01CA204446 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2017 to 2021
$2.0M
Tunable microbubbles for antivascular ultrasoundR01EB022612 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2016 to 2019
$1.6M
Integrated photoacoustic and ultrasound imaging with the Vevo LAZRS10OD016310 · OD · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2014 to 2014
$494k
NCI NIH HHS R01 CA204446NIBIB NIH HHS R01 EB022612NIH HHS S10 OD016310
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly vascular solid tumor. We have previously shown that ultrasound (US) therapy significantly reduces tumor vascularity. This study monitors US-induced changes in tumor oxygenation on murine HCC by photoacoustic imaging (PAI). Oxygen saturation and total hemoglobin were assessed by PAI before and after US treatments performed at different intensities of continuous wave (CW) bursts and pulsed wave (PW) bursts US. PAI revealed significant reduction both in HCC oxygen saturation and in total hemoglobin, proportional to the US intensity. Both CW bursts US (1.6 W/cm

Indexed as

Oxygen SaturationAnimalsCarcinoma, HepatocellularLiverLiver Neoplasms, ExperimentalMaleMiceMice, NudeNeoplasm TransplantationPhotoacoustic TechniquesUltrasonic Therapy

Identifiers

PMID33603035
PMCPMC7893035
OpenAlexW3129672603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.