ArticleScientific reports2021
Flexible brain dynamics underpins complex behaviours as observed in Parkinson's disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson's disease progression.GeroScience · 2026Article
- Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation.Journal of neuroengineering and rehabilitation · 2026Article
- The role of high-amplitude bursts of high-gamma activity in naturalistic speech and music listening.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms.eLife · 2025Article
- L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis.Human brain mapping · 2025Article
- Magnetoencephalography Dimensionality Reduction Informed by Dynamic Brain States.The European journal of neuroscience · 2025Article
- The Virtual Parkinsonian patient.NPJ systems biology and applications · 2025Article
- Analyzing Information Exchange in Parkinson's Disease via Eigenvector Centrality: A Source-Level Magnetoencephalography Study.Journal of clinical medicine · 2025Article
- Mapping and modeling age-related changes in intrinsic neural timescales.Communications biology · 2025Article
- Intermodal Consistency of Whole-Brain Connectivity and Signal Propagation Delays.Human brain mapping · 2025Article
- Enhanced brain network flexibility by physical exercise in female methamphetamine users.Cognitive neurodynamics · 2024Article
- EEG microstate transition cost correlates with task demands.PLoS computational biology · 2024Article
- Critical dynamics in spontaneous EEG predict anesthetic-induced loss of consciousness and perturbational complexity.Communications biology · 2024Article
- The virtual multiple sclerosis patient.iScience · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
- Virtual brain twins: from basic neuroscience to clinical use.National science review · 2024Review
- Local signal variability and functional connectivity: Sensitive measures of the excitation-inhibition ratio?Cognitive neurodynamics · 2024Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson's disease (PD). To test this hypothesis, we studied the 'functional repertoire'-the number of distinct configurations of neural activity-using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD relate to impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for correct behaviour.
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