ArticleScientific reports2021
Early protein intake predicts functional connectivity and neurocognition in preterm born children.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Early versus late administration of amino acids in preterm infants receiving parenteral nutrition.The Cochrane database of systematic reviews · 2024Pooled it
- Randomized Trial of Early Enhanced Parenteral Nutrition and Later Neurodevelopment in Preterm Infants.Nutrients · 2022Trial
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Association Between Maternal Angiogenic Markers in Hypertensive Disorders of Pregnancy and Neonatal Growth and Body Composition.Nutrients · 2026Article
- Clinical evaluation of a novel preterm standardised parenteral nutrition system for targeted macronutrient delivery.Pediatric research · 2026Article
- Article
- Parietal thickness predicts middle temporal area (V5) motion responses in 7-year-old children born very preterm.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Impact of early neonatal nutrition on neurodevelopment and the limbic system in very low birth weight infants.The British journal of nutrition · 2026Observational
- Neonatal neuroplasticity and metaplasticity: bridging neuroscience to clinical practice.Pediatric research · 2026Review
- Impact of colostrum oropharyngeal immunotherapy on postnatal growth in preterm infants based on early gut microbiota-host interaction patterns: protocol for a randomized controlled trial.International breastfeeding journal · 2025Article
- Early Nutrition is Associated With Global Motion Perception and V5 Function in 7-Year-Old Children Born Very Preterm.Human brain mapping · 2025Article
- Neonatal Nutrition and Brain Structure at 7 Years in Children Born Very Preterm.JAMA network open · 2025Article
- Lactoferrin intake from maternal milk during the neonatal hospitalization and early brain development among preterm infants.Pediatric research · 2024Article
- Protein Nutrition: Understanding Structure, Digestibility, and Bioavailability for Optimal Health.Foods (Basel, Switzerland) · 2024Review
- Maternal Diet Influences Human Milk Protein Concentration and Adipose Tissue Marker.Nutrients · 2023Article
- Article
- Social-Cognitive Network Connectivity in Preterm Children and Relations With Early Nutrition and Developmental Outcomes.Frontiers in systems neuroscience · 2022Article
- Association Between Early Amino Acid Intake and Full-Scale IQ at Age 5 Years Among Infants Born at Less Than 30 Weeks' Gestation.JAMA network open · 2021Article
- Nutritional Intake, White Matter Integrity, and Neurodevelopment in Extremely Preterm Born Infants.Nutrients · 2021Article
- Optimizing Early Neonatal Nutrition and Dietary Pattern in Premature Infants.International journal of environmental research and public health · 2021Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks' gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = - 0.06; 95% CI - 0.09, - 0.02, p = 0.001) and carbohydrates (β = - 0.03; 95% CI - 0.04, - 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.
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Registered trials
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