Evidence map›Paper›PMID 33602901›Full record

ArticleBlood cancer journal2021

Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment.

Hilma J van der Horst, A Vera de Jonge, Ida H Hiemstra, Anne T Gelderloos, Daniella R A I Berry, Nathalie J Hijmering, Hendrik F van Essen, Daphne de Jong, Martine E D Chamuleau, Sonja Zweegman and 3 more

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 94 citations in OpenAlex.

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  15. Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Development and biomarkers of CD20/CD3 bispecific antibodies in diffuse large B-cell lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2025
    Review
  18. Review
  19. Treatment with epcoritamab in 10 patients in real-world clinical practice.Journal of clinical and experimental hematopathology : JCEH · 2024
    Article
  20. Sequencing bispecific antibodies and CAR T cells for FL.Hematology. American Society of Hematology. Education Program · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Hilma J van der HorstDepartment of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.ORCID 0000-0002-7997-1138
A Vera de JongeDepartment of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.ORCID 0000-0002-5397-1762
Ida H HiemstraGenmab, Utrecht, Netherlands.
Anne T GelderloosDepartment of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Daniella R A I BerryDepartment of Pathology, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Nathalie J HijmeringDepartment of Pathology, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Hendrik F van EssenDepartment of Pathology, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Daphne de JongDepartment of Pathology, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.ORCID 0000-0002-9725-4060
Martine E D ChamuleauDepartment of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Sonja ZweegmanDepartment of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.
Esther C W BreijGenmab, Utrecht, Netherlands.ORCID 0000-0002-5368-6849
Margaretha G M Roemer *Department of Pathology, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands.ORCID 0000-0003-0220-3496
Tuna Mutis *Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, Location VUMC, Amsterdam, Netherlands. t.mutis@amsterdamumc.nl.ORCID 0000-0002-5557-7187
Amsterdam University Medical Centers · NLGenmab (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epcoritamab (DuoBody-CD3xCD20, GEN3013) is a novel bispecific IgG1 antibody redirecting T-cells toward CD20

Indexed as

Antibodies, BispecificAntigens, CD20Antineoplastic Agents, ImmunologicalB-LymphocytesCell Line, TumorHumansLymphocyte ActivationLymphoma, FollicularLymphoma, Large B-Cell, DiffuseLymphoma, Mantle-CellTumor Cells, CulturedAntibodies, BispecificAntigens, CD20Antineoplastic Agents, Immunological

Identifiers

PMID33602901
PMCPMC7892878
OpenAlexW3131466578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.