Evidence map›Paper›PMID 33602820›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite

Mi Cheong Cheong, Zhu Wang, Tegegn G Jaleta, Xinshe Li, James B Lok, Steven A Kliewer, David J Mangelsdorf

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  10. Invade or die: behaviours and biochemical mechanisms that drive skin penetration inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  11. A standard workflow for community-driven manual curation ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Host genetic backgrounds: the key to determining parasite-host adaptation.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Molecular Cloning and Characterization of aPathogens (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mi Cheong CheongDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-7604-6203
Zhu WangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-0768-0988
Tegegn G JaletaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Xinshe LiDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
James B LokDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-7611-8211
Steven A KliewerDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Steven.Kliewer@UTSouthwestern.edu davo.mango@utsouthwestern.edu.ORCID 0000-0001-5161-641X
David J MangelsdorfDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Steven.Kliewer@UTSouthwestern.edu davo.mango@utsouthwestern.edu.ORCID 0000-0002-4355-0796
The University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · US

Funding

INSULIN-LIKE SIGNALING IN PARASITIC NEMATODE DEVELOPMENTR01AI050668 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2002 to 2023
$7.1M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
Mechanisms and Treatment of Chronic, Latent Human StrongyloidiasisR33AI105856 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABRAHAM, DAVID, LOK, JAMES B · 2015 to 2017
$1.4M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI050668NIAID NIH HHS R01 AI164715NIAID NIH HHS R33 AI105856
6 · The paper itself

Abstract

DAF-12 is nematode-specific nuclear receptor that has been proposed to govern development of the infectious stage of parasitic species, including

Indexed as

Gene Expression Regulation, DevelopmentalAmino Acid SequenceAnimalsBase SequenceCaenorhabditis elegansCaenorhabditis elegans ProteinsCRISPR-Cas SystemsLarvaReceptors, Cytoplasmic and NuclearStrongyloides stercoralisTranscription FactorsCaenorhabditis elegans ProteinsDAF-12 protein, C elegansReceptors, Cytoplasmic and NuclearTranscription FactorscoactivatorDAF-12nematode parasitenuclear receptorStrongyloides stercoralis

Identifiers

PMID33602820
PMCPMC7923533
OpenAlexW3131347573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.