ArticlePediatrics2021
Maternal Chronic Conditions and Risk of Cerebral Palsy in Offspring: A National Cohort Study.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Fertility treatment and risk of cerebral palsy: has the association changed in Australia?Human reproduction (Oxford, England) · 2026Article
- The impact of prepregnancy BMI and family history of diabetes on the prevalence of gestational diabetes mellitus among Bulgarian women.BMC pregnancy and childbirth · 2026Observational
- Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children.BMC medicine · 2026Article
- A sibling study of the prenatal and perinatal risks for cerebral palsy.Pediatric research · 2025Article
- Well controlled maternal inflammatory bowel disease does not increase the risk of abnormal neurocognitive outcome screening in offspring.Brain, behavior, & immunity - health · 2024Article
- Pre-pregnancy and pregnancy disorders, pre-term birth and the risk of cerebral palsy: a population-based study.International journal of epidemiology · 2023Article
- Association of placental and umbilical cord characteristics with cerebral palsy: national cohort study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Somatic comorbidities of mental disorders in pregnancy.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Maternal Multiple Sclerosis and Health Outcomes Among the Children: A Systematic Review.Clinical epidemiology · 2023Review
- Neurodevelopmental outcomes of infants of diabetic mothers.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsReview
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPrevious studies suggest that children of mothers with certain chronic conditions may be at increased risk of cerebral palsy (CP). We explored possible associations between 17 maternal chronic conditions and CP in offspring.
methodsWe conducted a prospective cohort study of Norwegian children born in 1990-2012 and surviving to 2 years of age. Information on maternal chronic conditions during pregnancy were extracted from the Medical Birth Registry of Norway (1990-2012). Information on chronic conditions in mothers and fathers recorded in the Norwegian Patient Registry (2008-2014) was available for a subset of children. CP diagnoses were extracted from the National Insurance Scheme (1990-2014) and the Norwegian Patient Registry (2008-2014). We estimated relative risks (RRs) and 95% confidence intervals (CIs) of CP in offspring of parents with chronic conditions compared with the general population using log binominal regression models.
resultsA total of 1 360 149 Norwegian children, including 3575 children with CP (2.6 per 1000 live births), fulfilled the inclusion criteria. The highest risk of CP was among offspring of mothers with type 2 diabetes (RR 3.2; 95% CI 1.8-5.4), lupus erythematosus (RR 2.7; 95% CI 0.9-8.3), type 1 diabetes (RR 2.2; 95% CI 1.4-3.4), and Crohn disease (RR 2.1; 95% CI 1.0-4.1) during pregnancy. No increased risks were seen for offspring of fathers with chronic conditions.
conclusionsSeveral maternal chronic conditions were associated with increased risk of CP in offspring. Maternal autoimmune disorders carried a particular risk.
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