Evidence map›Paper›PMID 33602371›Full record

ArticleBJPsych open2021

The efficacy of antidepressant medication and interpersonal psychotherapy for adult acute-phase depression: study protocol of a systematic review and meta-analysis of individual participant data.

Ellen Driessen, Zachary D Cohen, Myrna M Weissman, John C Markowitz, Erica S Weitz, Steven D Hollon, Dillon T Browne, Paola Rucci, Carolina Corda, Marco Menchetti and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 17 institutions in 5 countries.

Ellen DriessenDepartment of Clinical Psychology, Behavioural Science Institute, Radboud University, the Netherlands; and Depression Expertise Center, Pro Persona Mental Health Care, the Netherlands.ORCID https://orcid.org/0000-0002-9602-1548
Zachary D CohenDepartment of Psychiatry, University of California Los Angeles, USA.ORCID https://orcid.org/0000-0002-4883-1028
Myrna M WeissmanColumbia University Vagelos College of Physicians & Surgeons, New York State Psychiatric Institute, USA.
John C MarkowitzColumbia University Vagelos College of Physicians & Surgeons, New York State Psychiatric Institute, USA.
Erica S WeitzDepartment of Psychology, University of Pennsylvania, USA.
Steven D HollonDepartment of Psychology, Vanderbilt University, USA.
Dillon T BrowneDepartment of Psychology, University of Waterloo, Canada.
Paola RucciDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Italy.
Carolina CordaDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Marco MenchettiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Italy.
R Michael BagbyDepartments of Psychology and Psychiatry, and Graduate Department of Psychological Clinical Science, University of Toronto Scarborough, Canada.
Lena C QuiltyDepartment of Psychiatry, University of Toronto, Canada.
Michael W O'HaraDepartment of Psychological and Brain Sciences, University of Iowa, USA.ORCID https://orcid.org/0000-0003-1796-0449
Caron ZlotnickDepartments of Psychiatry and Human Behavior, Medicine, and Obstetrics and Gynecology, Brown University, USA; and Butler Hospital, USA.
Teri PearlsteinAlpert Medical School of Brown University, USA.
Marc B J BlomParnassia Groep, the Netherlands.
Mario AltamuraDepartment of Clinical and Experimental Medicine, University of Foggia, Italy.
Carlos GoisDepartment of Psychiatry, University of Lisbon, Portugal.
Lon S SchneiderDepartment of Psychiatry and Neuroscience, Keck School of Medicine of USC, USA.
Jos W R TwiskDepartment of Epidemiology and Biostatistics, Amsterdam University Medical Centers, the Netherlands.
Pim CuijpersDepartment of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-5497-2743
University of Bologna · ITNew York State Psychiatric InstituteUniversity of Toronto · CAAmsterdam University Medical Centers · NLBrown University · USJohn Brown University · USKeck Hospital of USC · USParnassia Groep · NLRadboud University Nijmegen · NLUniversity of California, Los Angeles · USUniversity of Foggia · ITUniversity of Iowa · USUniversity of Lisbon · PTUniversity of Pennsylvania · USUniversity of Waterloo · CAVanderbilt University · USVrije Universiteit Amsterdam · NL

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VINTERS, HARRY V. · 1994 to 2012
$26.4M
NIA NIH HHS P01 AG012435NIA NIH HHS P30 AG066530
6 · The paper itself

Abstract

backgroundAntidepressant medication and interpersonal psychotherapy (IPT) are both recommended interventions in depression treatment guidelines based on literature reviews and meta-analyses. However, 'conventional' meta-analyses comparing their efficacy are limited by their reliance on reported study-level information and a narrow focus on depression outcome measures assessed at treatment completion. Individual participant data (IPD) meta-analysis, considered the gold standard in evidence synthesis, can improve the quality of the analyses when compared with conventional meta-analysis.

aimsWe describe the protocol for a systematic review and IPD meta-analysis comparing the efficacy of antidepressants and IPT for adult acute-phase depression across a range of outcome measures, including depressive symptom severity as well as functioning and well-being, at both post-treatment and follow-up (PROSPERO: CRD42020219891).

methodWe will conduct a systematic literature search in PubMed, PsycINFO, Embase and the Cochrane Library to identify randomised clinical trials comparing antidepressants and IPT in the acute-phase treatment of adults with depression. We will invite the authors of these studies to share the participant-level data of their trials. One-stage IPD meta-analyses will be conducted using mixed-effects models to assess treatment effects at post-treatment and follow-up for all outcome measures that are assessed in at least two studies.

conclusionsThis will be the first IPD meta-analysis examining antidepressants versus IPT efficacy. This study has the potential to enhance our knowledge of depression treatment by comparing the short- and long-term effects of two widely used interventions across a range of outcome measures using state-of-the-art statistical techniques.

Indexed as

antidepressant medicationDepressionefficacyindividual participant data meta-analysisinterpersonal psychotherapy

Identifiers

PMID33602371
PMCPMC8058821
OpenAlexW3132075534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.