ArticleBMC gastroenterology2021
Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia.
Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia with sleep disturbance via enhanced vagal activity: a randomized controlled trial.International journal of surgery (London, England) · 2026Trial
- Sleep and Disorders of Gut-Brain Interaction.Gastroenterology & hepatology · 2026Article
- Analysis of the mediating effect of sleep quality between anxiety state and quality of life in patients with functional dyspepsia.Frontiers in psychiatry · 2026Article
- Postprandial attenuation of gastric slow waves in anxiety-depression, with and without functional dyspepsia: associations with heart rate variability and sleep quality.Frontiers in medicine · 2026Article
- Analysis of autonomic function in patients with functional dyspepsia using real-time wearable devices and smartphone applications.Journal of clinical biochemistry and nutrition · 2025Article
- Exploring the Connection between Sleep Disorders, Emotional Distress, and Quality of Life in Functional Dyspepsia.Actas espanolas de psiquiatria · 2025Article
- Associations Between Sleep Quality, Anxiety, Depression, and Gastroesophageal Reflux Disease in a Tertiary Hospital Sleep Center: A Retrospective Study.International journal of general medicine · 2025Article
- Pathophysiological mechanisms of functional dyspepsia: a narrative review.Frontiers in medicine · 2025Article
- Review
- Article
- Scoping review: the social and emotional impacts of gastroparesis.Translational gastroenterology and hepatology · 2024Article
- Sleep quality and clinical association with sleep disturbance in systemic sclerosis.BMC rheumatology · 2023Article
- Sleep Quality and Insomnia Are Associated With Quality of Life in Functional Dyspepsia.Frontiers in neuroscience · 2022Article
- Moxibustion Regulates Gastrointestinal Motility via HCN1 in Functional Dyspepsia Rats.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsFunctional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between FD and sleep disturbance.
methodsWe prospectively enrolled 20 FD patients with sleep disturbance between December 2018 and July 2019. Patients took sleep aids for 4 weeks and filled out questionnaires before and after taking sleep aids. Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Athens Insomnia Scale (AIS) were used to evaluate the severity of their sleep disturbance. Modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (mFSSG), Gastrointestinal Symptom Rating Scale (GSRS), and the Japanese version of Patient Assessment of Constipation Quality of Life (JPAC-QOL) were used to evaluate the severity of GI symptoms. Short-Form 36-Item Health Survey (SF-36) was used to evaluate QOL. Pre- and post-sleep medication values of questionnaires were compared.
resultsAmong 20 enrolled patients, 16 completed the study protocol. Zolpidem, eszopiclone, and suvorexant were administered to six, nine, and one patient, respectively. Each median total score of questionnaires (pre-/post-sleep medication, respectively) was as follows: PSQI, 10.0/8.5; ESS, 12.5/5.0; AIS, 10.0/4.0; mFSSG, 21.0/16.0; GSRS, 44.0/31.0 (Pain in GSRS, 11.0/5.0); JPAC-QOL, 26.0/15.5; SF-36, 63.9/71.9. All of these results showed statistically significant differences between pre- and post-sleep medication (p < 0.05).
conclusionsImprovement of sleep disturbance by administration of sleep aids resulted in improvement of GI symptoms and QOL in patients with FD. This effect may be related to pain modification.
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