ArticleBMC infectious diseases2021
Endemic chikungunya fever in Kenyan children: a prospective cohort study.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Evidence of Chikungunya Virus Reinfection in Two Patients With Lupus During the 2024-2025 Outbreak on Reunion Island.Open forum infectious diseases · 2026Article
- Mitochondrial phylogeography and insecticide resistance of Aedes aegypti in Kenya.PLoS neglected tropical diseases · 2026Article
- Investigation of chikungunya arbovirus in cities of Bushehr province: An ELISA-based cross-sectional study.Virus research · 2026Article
- Cross- Wellcome Africa Asian Programmes (AAPs) Acceleration of Genomics for Escalating infectious Diseases, (CAGED) Consortium.Wellcome open research · 2026Article
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- Chikungunya virus seroprevalence among febrile patients in selected health facilities in Mount Elgon region, Kenya.PLoS neglected tropical diseases · 2025Article
- Role of invasive Aedes (Aedimorphus) vittatus in chikungunya virus transmission in the newly-invaded coastal island city of Mombasa, Kenya.PLoS neglected tropical diseases · 2025Article
- Predicting the ecological niches ofFrontiers in tropical diseases · 2025Article
- Continuous detection of Chikungunya Virus in a passive surveillance system in southern Thailand, 2012-2019.PLoS neglected tropical diseases · 2025Article
- Understanding the Transmission Dynamics of the Chikungunya Virus in Africa.Pathogens (Basel, Switzerland) · 2024Review
- Programmatic considerations and evidence gaps for chikungunya vaccine introduction in countries at risk of chikungunya outbreaks: Stakeholder analysis.PLoS neglected tropical diseases · 2024Article
- Trends in emerging vector-borne viral infections and their outcome in children over two decades.Pediatric research · 2024Review
- Advances in the Development of Non-Structural Protein 1 (NsP1) Inhibitors for the Treatment of Chikungunya Virus Infection.Mini reviews in medicinal chemistry · 2024Review
- Acute febrile illness in Kenya: Clinical characteristics and pathogens detected among patients hospitalized with fever, 2017-2019.PloS one · 2024Article
- Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need.NPJ vaccines · 2023Review
- Chikungunya outbreak in Africa: a review of the literature.Annals of medicine and surgery (2012) · 2023Article
- What does equitable global health research and delivery look like? Tackling Infections to Benefit Africa (TIBA) partnership as a case study.BMJ global health · 2023Article
- Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development.Viruses · 2022Review
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Authors and funding
16 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundChikungunya fever (CHIKF) was first described in Tanzania in 1952. Several epidemics including East Africa have occurred, but there are no descriptions of longitudinal surveillance of endemic disease. Here, we estimate the incidence of CHIKF in coastal Kenya and describe the associated viral phylogeny.
methodsWe monitored acute febrile illnesses among 3500 children visiting two primary healthcare facilities in coastal Kenya over a 5-year period (2014-2018). Episodes were linked to a demographic surveillance system and blood samples obtained. Cross-sectional sampling in a community survey of a different group of 435 asymptomatic children in the same study location was done in 2016. Reverse-transcriptase PCR was used for chikungunya virus (CHIKV) screening, and viral genomes sequenced for phylogenetic analyses.
resultsWe found CHIKF to be endemic in this setting, associated with 12.7% (95% CI 11.60, 13.80) of all febrile presentations to primary healthcare. The prevalence of CHIKV infections among asymptomatic children in the community survey was 0.7% (95% CI 0.22, 2.12). CHIKF incidence among children < 1 year of age was 1190 cases/100,000-person years and 63 cases/100,000-person years among children aged ≥10 years. Recurrent CHIKF episodes, associated with fever and viraemia, were observed among 19 of 170 children with multiple febrile episodes during the study period. All sequenced viral genomes mapped to the ECSA genotype albeit distinct from CHIKV strains associated with the 2004 East African epidemic.
conclusionsCHIKF may be a substantial public health burden in primary healthcare on the East African coast outside epidemic years, and recurrent infections are common.
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