Trial reportJournal of affective disorders2021
Losing trust in body sensations: Interoceptive awareness and depression symptom severity among primary care patients.
Trial report in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The Effectiveness of Mindfulness-Based Interventions for Depressive Symptoms and Their Relationship to Interoceptive Awareness: A Systematic Review.Alpha psychiatry · 2025Pooled it
- Disrupted profiles of interoception and mental health in youths: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- The Role of Self-Compassion and Body Perception in Predicting Psychological Safety.Journal of clinical medicine · 2026Article
- A Network Analysis of Alexithymia, Interoception, Empathy, Self-Awareness and Psychopathological Symptoms in Young People With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Estimating Interoceptive Sensitivity from Physiological Breathing Parameters.Journal of the Royal Society of New Zealand · 2026Article
- The cognitive and motor determinants of the perception of effort.Cognitive, affective & behavioral neuroscience · 2026Article
- Role of childhood trauma in interoception and alexithymia in schizophrenia.Journal of psychiatric research · 2026Article
- Interoception in obsessive-compulsive and major depressive disorders.Frontiers in psychology · 2026Article
- From the body to the mind: interoception and sense of agency as mechanisms of depression reduction in the Body-Mind Axial Awareness (BMAA).Frontiers in psychology · 2026Article
- No more counting sheep? Interoceptive not-distracting as a novel predictor of insomnia symptom severity in college students.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Hemispheric disconnection as a basis for neurodegeneration in apraxia and Alzheimer's disease.Discover mental health · 2025Review
- We have liftoff: A discovery study to use artificial intelligence to identify adaptative profiles for future space missions.Physiological reports · 2025Article
- The Effect Emotion Regulation Difficulties on Interoceptive Awareness and Alexithymia: An Example of Consultation-Liaison Psychiatry.Psychiatry investigation · 2025Article
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- A cross-sectional study on the relationship between interoceptive sensitivity and somatic symptoms in young bipolar disorder patients.BMC psychiatry · 2025Article
- The Future of Perceptual Dysregulation in Psychiatric Nosology.Current topics in behavioral neurosciences · 2025Review
- The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations.Current topics in behavioral neurosciences · 2025Review
- Exploring the relationship between cardiac awareness and balance.Scientific reports · 2024Article
- Interoception in pregnancy: Implications for peripartum depression.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInteroceptive dysfunction is emerging as an important biomarker for mental illnesses, such as depression which is a leading cause of disability and death worldwide. Little empirical research explains the relationship between interoception and depression.
methodsUsing multivariable linear regression models and cross-sectional baseline data from a randomized control trial of primary care patients (N = 281), we analyzed the relationship between depression severity (none/slight, mild, and moderate/severe via the PROMIS depression scale) and the Multidimensional Assessment of Interoceptive Awareness (MAIA) subscales (noticing, not distracting, not worrying, attention regulation, emotional awareness, selfregulation, body listening and trusting).
resultsAdjusted results suggest moderate/severe depression was inversely associated with body trusting (p < .001), body listening (p < .01), noticing (p < .01), emotional awareness (p < .01), and self-regulation (p < .05). Mild depression was inversely associated with body trusting (p <.01). After correction for multiple comparisons, the relationship between MAIA body trusting and mild and moderate/severe depression remained significant. LIMITATIONS: Our findings may not be generalizable to other populations or healthcare settings. Additionally, findings cannot be interpreted as causal due to our inability to establish temporality.
conclusionsLack of body trust appears important for understanding how individuals with depression interpret or respond to interoceptive stimuli and may represent the leading edge of interoceptive dysregulation seen in depressive disorders. Our findings support a hypothesis about mechanisms of action underlying hypoactivation in depression. Further, these results support clinical identification of subtypes of depression, such as those with high levels of co-occurring anxiety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.