Evidence map›Paper›PMID 33601674›Full record

ArticleJournal of affective disorders2021

Validation of brief screening measures for depression and anxiety in young people with substance use disorders.

Kate H Bentley, Hitoshi Sakurai, Kelsey L Lowman, Lisa Rines-Toth, James McKowen, Paola Pedrelli, A Eden Evins, Amy M Yule

Abstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  5. Discrimination and Mental Health in an Ethnically Diverse Sample of Black Youth.Journal of racial and ethnic health disparities · 2025
    Article
  6. Article
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  8. Psychological Distress is Associated With Blunt Use Among Youth in the United States: Insights From the 2021-2023 National Youth Tobacco Surveys.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  9. Co-creating a youth development survey with racial, ethnic, and gender diverse young people: Examining psychometric properties and measurement invariance.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025
    Article
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  16. Psychological Distress and Cannabis Vaping Among U.S. Adolescents.American journal of preventive medicine · 2024
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kate H BentleyDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States. Electronic address: KBENTLEY@mgh.harvard.edu.
Hitoshi SakuraiDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States; Department of Neuropsychiatry, Keio University School of Medicine, United States.
Kelsey L LowmanDepartment of Psychiatry, Massachusetts General Hospital, United States.
Lisa Rines-TothDepartment of Psychiatry, Massachusetts General Hospital, United States.
James McKowenDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
Paola PedrelliDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
A Eden EvinsDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
Amy M YuleDepartment of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States; Department of Psychiatry, Boston Medical Center, United States; Boston University School of Medicine, United States.

Funding

AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Career Development Program in Substance Use and Addiction MedicineK12DA043490 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI A EDEN EVINS, NANCY A RIGOTTI · 2017 to 2026
$4.7M
Digital Monitoring of Agitation for Short-Term Suicide Risk PredictionK23MH120436 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BENTLEY, KATE H. · 2019 to 2024
$1.0M
NIDA NIH HHS K12 DA000357NIDA NIH HHS K12 DA043490NIMH NIH HHS K23 MH120436
6 · The paper itself

Abstract

backgroundIt is critical to promptly identify and monitor mood and anxiety symptoms in young people with SUD. The primary aim of this study was to conduct a psychometric validation of the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder scale (GAD-7) for depression and anxiety screening in young people seeking outpatient treatment for SUD. Our secondary aim was to compare the performance of the PHQ-9 and GAD-7 to their briefer two-item versions (PHQ-2 and GAD-2) in terms of detecting probable mood and anxiety disorders.

methodData were extracted from the electronic health records of patients (ages 14 to 26) who received a diagnostic evaluation following clinical implementation of the PHQ-9 and GAD-7 at a hospital-based outpatient SUD treatment program (N=121, average age 19.1 ± 3.1 years).

resultsThe PHQ-9 and GAD-7 showed excellent internal consistency. A PHQ-9 cut score of 7 or 8 (PHQ-2 cut score: 2) and GAD-7 cut score of 6 (GAD-2 cut score: 2) had the best balance of sensitivity, specificity, and positive and negative predictive power in these data. These measures also showed good convergent and acceptable discriminant validity. LIMITATIONS: The sample was predominantly White and non-Hispanic, and a validated (semi-)structured diagnostic interview was not used to establish mood and anxiety disorder diagnoses.

conclusionsResults suggest the PHQ-9 and GAD-7 are reliable and potentially clinically useful screening tools for depression and anxiety in young people with SUD, and that the two-item versions may have similar clinical utility as the full measures.

Indexed as

DepressionSubstance-Related DisordersAdolescentAdultAnxietyAnxiety DisordersHumansMass ScreeningPatient Health QuestionnairePsychometricsReproducibility of ResultsSurveys and QuestionnairesYoung AdultAdolescentsAnxietyDepressionScreeningSubstance use disorderYoung adults

Identifiers

PMID33601674
PMCPMC7896042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.