Evidence map›Paper›PMID 33601417›Full record

ArticleThe Journal of experimental medicine2021

Gatekeepers of the fetus: Characterization of placental macrophages.

Christina Megli, Carolyn B Coyne

Abstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Subtype specific immune-metabolic reprogramming in preeclampsia revealed by multiomics and serum biomarkers.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  12. Innate immune defenses at the maternal-fetal interface.Current opinion in immunology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Christina MegliDivision of Maternal-Fetal Medicine, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA.
Carolyn B CoyneDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA.

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
Enterovirus Infection of Polarized Intestinal CellsR01AI081759 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COYNE, CAROLYN B · 2009 to 2024
$5.0M
Innate Immune Regulation of Zika Virus InfectionR01AI145296 · NIAID · UNIVERSITY OF WASHINGTON · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$4.1M
Innate immune signaling in placental antiviral defensesR01AI145828 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$3.5M
The Role of FcRn in Echovirus Entry and PathogenesisR01AI150151 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COYNE, CAROLYN B · 2020 to 2024
$2.4M
Enterovirus Infection of Polarized Intestinal CellsR56AI081759 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COYNE, CAROLYN B · 2013 to 2019
$749k
Medical Research Council MR/P001092/1NIAID NIH HHS R01 AI081759NIAID NIH HHS R01 AI145296NIAID NIH HHS R01 AI145828NIAID NIH HHS R01 AI150151NIAID NIH HHS R56 AI081759NICHD NIH HHS K12 HD000849
6 · The paper itself

Abstract

In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal-fetal interface. Using new isolation strategies to better separate maternal- and fetal-derived cells, the authors identify previously undefined maternal-derived immune cells associated with the fetal-derived placenta and provide an in-depth analysis of the markers and characteristics of placental Hofbauer cells.

Indexed as

FetusPlacentaFemaleHumansMacrophagesPregnancy

Identifiers

PMID33601417
PMCPMC7754679

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.