Evidence map›Paper›PMID 33601187›Full record

ArticleNuclear medicine and biology

Synthesis and preliminary evaluation of

Ganesan Vaidyanathan, Ronnie C Mease, Il Minn, Jaeyeon Choi, Ying Chen, Hassan Shallal, Choong Mo Kang, Darryl McDougald, Vivek Kumar, Martin G Pomper and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Effective treatment of human prostate carcinoma xenografts with Single-Dose PSMA-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Advances in PSMA theranostics.Translational oncology · 2022
    Article
  13. An ImprovedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  14. Review
  15. Review
  16. A third generation PSMA-targeted agent [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, NC, USA.
Ronnie C MeaseRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Il MinnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jaeyeon ChoiDepartment of Radiology, Duke University Medical Center, Durham, NC, USA.
Ying ChenRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hassan ShallalRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Choong Mo KangDepartment of Radiology, Duke University Medical Center, Durham, NC, USA.
Darryl McDougaldDepartment of Radiology, Duke University Medical Center, Durham, NC, USA.
Vivek KumarRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC, USA. Electronic address: zalut001@mc.duke.edu.
Johns Hopkins University · USDuke Medical Center · US

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
NCI NIH HHS R01 CA134675NCI NIH HHS R01 CA184228NIBIB NIH HHS P41 EB024495
6 · The paper itself

Abstract

introductionThe high potency and short tissue range of α-particles are attractive features for targeted radionuclide therapy, particularly for cancers with micro-metastases. In the current study, we describe the synthesis of a series of

methodsFour novel Glu-urea based PSMA ligands containing a trialkyl stannyl group were synthesized and labeled with

resultsRadiochemical yields ranged from 32% to 65% for the CONCLUSIONS AND IMPLICATIONS FOR PATIENT CARE: Compared with the first generation compound [

Indexed as

Alpha ParticlesAntigens, SurfaceAstatineChemistry Techniques, SyntheticGlutamate Carboxypeptidase IIIsotope LabelingProstatic NeoplasmsAnimalsCell Line, TumorHumansMaleMiceMolecular Targeted TherapyRadiochemistryTissue DistributionAntigens, SurfaceAstatineAstatine-211FOLH1 protein, humanGlutamate Carboxypeptidase IIAlpha emitterAstatineProstate cancerProstate-specific membrane antigenRadionuclide therapy

Identifiers

PMID33601187
PMCPMC7987787
OpenAlexW3122630556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.