ArticleClinical imaging2021
Coronary artery calcification in COVID-19 patients: an imaging biomarker for adverse clinical outcomes.
Article in Clinical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Systematic review and meta-analysis on coronary calcifications in COVID-19.Emergency radiology · 2022Pooled it
- A Meta-Analysis: Coronary Artery Calcium Score and COVID-19 Prognosis.Medical sciences (Basel, Switzerland) · 2022Pooled it
- Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis.International immunopharmacology · 2022Pooled it
- Prognostic value of deep learning-based coronary artery calcium score and quantitative pneumonia burden in patients hospitalized with COVID-19.BMC medical imaging · 2026Article
- Phenotypic switch of vascular smooth muscle cells in COVID-19: Role of cholesterol, calcium, and phosphate.Journal of cellular physiology · 2024Review
- Beyond the Heart: The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification.Diagnostics (Basel, Switzerland) · 2024Review
- Prognostic Value of Coronary Artery Calcification in Patients with COVID-19 and Interstitial Pneumonia: A Case-Control Study.Journal of cardiovascular development and disease · 2024Article
- Coronary artery calcification score as a prognostic indicator for COVID-19 mortality: evidence from a retrospective cohort study in Iran.Annals of medicine and surgery (2012) · 2024Article
- Application of deep learning and feature selection technique on external root resorption identification on CBCT images.BMC oral health · 2024Article
- Correlation between coronary artery calcification and COVID-19.Caspian journal of internal medicine · 2024Article
- Article
- Imaging for Cardiovascular Complications of COVID-19: Cardiac Manifestations in Context.The Canadian journal of cardiology · 2023Review
- Coronary artery calcification as a predictor of adverse outcomes in patients hospitalized with COVID-19.American heart journal plus : cardiology research and practice · 2023Article
- Role of the coronary and non-coronary cardiovascular findings on non-cardiac gated thoracic CT in predicting mortality in SARS-CoV-2 infection.Clinical imaging · 2022Article
- Vascular Implications of COVID-19: Role of Radiological Imaging, Artificial Intelligence, and Tissue Characterization: A Special Report.Journal of cardiovascular development and disease · 2022Review
- Lung Opacity and Coronary Artery Calcium Score: A Combined Tool for Risk Stratification and Outcome Prediction in COVID-19 Patients.Academic radiology · 2022Article
- Imaging of COVID-19.Seminars in roentgenology · 2022Article
- COVID-19, the Pandemic of the Century and Its Impact on Cardiovascular Diseases.Cardiology discovery · 2021Article
- The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification.GeroScience · 2021Article
- Teaching an old dog new tricks: The prognostic role of CACS in hospitalized COVID-19 patients.Atherosclerosis · 2021Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have demonstrated a complex interplay between comorbid cardiovascular disease, COVID-19 pathophysiology, and poor clinical outcomes. Coronary artery calcification (CAC) may therefore aid in risk stratification of COVID-19 patients.
methodsNon-contrast chest CT studies on 180 COVID-19 patients ≥ age 21 admitted from March 1, 2020 to April 27, 2020 were retrospectively reviewed by two radiologists to determine CAC scores. Following feature selection, multivariable logistic regression was utilized to evaluate the relationship between CAC scores and patient outcomes.
resultsThe presence of any identified CAC was associated with intubation (AOR: 3.6, CI: 1.4-9.6) and mortality (AOR: 3.2, CI: 1.4-7.9). Severe CAC was independently associated with intubation (AOR: 4.0, CI: 1.3-13) and mortality (AOR: 5.1, CI: 1.9-15). A greater CAC score (UOR: 1.2, CI: 1.02-1.3) and number of vessels with calcium (UOR: 1.3, CI: 1.02-1.6) was associated with mortality. Visualized coronary stent or coronary artery bypass graft surgery (CABG) had no statistically significant association with intubation (AOR: 1.9, CI: 0.4-7.7) or death (AOR: 3.4, CI: 1.0-12).
conclusionCOVID-19 patients with any CAC were more likely to require intubation and die than those without CAC. Increasing CAC and number of affected arteries was associated with mortality. Severe CAC was associated with higher intubation risk. Prior CABG or stenting had no association with elevated intubation or death.
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