SynthesisPhotodiagnosis and photodynamic therapy2021
A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2.
Synthesis in Photodiagnosis and photodynamic therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- RuvidarViruses · 2025Article
- Membrane-Targeting Antivirals.International journal of molecular sciences · 2025Review
- Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy.Nanomedicine (London, England) · 2025Review
- Investigation of the solubility of protoporphyrin IX in aqueous and hydroalcoholic solvent systems.Beilstein journal of nanotechnology · 2025Article
- Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses.Heliyon · 2024Article
- Combinations of Photodynamic Therapy with Other Minimally Invasive Therapeutic Technologies against Cancer and Microbial Infections.International journal of molecular sciences · 2023Review
- Photodynamic Therapy: From the Basics to the Current Progress ofMolecules (Basel, Switzerland) · 2023Review
- Review
- Photodynamic Inhibition of Herpes Simplex Virus 1 Infection by Tricationic Amphiphilic Porphyrin with a Long Alkyl Chain.Pharmaceutics · 2023Article
- Near-Infrared Dyes: Towards Broad-Spectrum Antivirals.International journal of molecular sciences · 2022Review
- Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives.Biomolecules · 2022Review
- Fluorine Atoms on CInternational journal of molecular sciences · 2022Article
- Photodynamic Inactivation of Microorganisms Using Semisynthetic ChlorophyllMolecules (Basel, Switzerland) · 2022Article
- Oral lesions and saliva alterations of COVID-19 patients in an intensive care unit: A retrospective study.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2022Article
- Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In Vitro.Viruses · 2022Article
- Infectivity and Morphology of Bovine Coronavirus Inactivated In Vitro by Cationic Photosensitizers.Viruses · 2022Article
- The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity.ACS applied materials & interfaces · 2022Article
- How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?Photodiagnosis and photodynamic therapy · 2022Review
- Photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in oral manifestations of patients infected by Sars-CoV-2: systematic review and meta-analysis.Bulletin of the National Research Centre · 2022Review
- Phototherapy and optical waveguides for the treatment of infection.Advanced drug delivery reviews · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation.
methodsThe focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?". A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses.
resultsFrom 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro, and two had in vitro/in vivo parts. Only one analyzed publication was exclusively in vivo. Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies.
conclusionThe in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.
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