Evidence map›Paper›PMID 33600908›Full record

ArticleNeuroscience letters2021

Investigating ELOVL7 coding variants in multiple system atrophy.

Anna I Wernick, Ronald L Walton, Alexandra I Soto-Beasley, Shunsuke Koga, Yingxue Ren, Michael G Heckman, Lukasz M Milanowski, Rebecca R Valentino, Naveen Kondru, Ryan J Uitti and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Cellular and systemic modifiers of alpha-synuclein proteostasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  2. Review
  3. The genetic basis of multiple system atrophy.Journal of translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Anna I WernickDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; School of Biological Sciences, University of Manchester, Manchester, UK; Queen Square Institute of Neurology, University College London, London, UK.
Ronald L WaltonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Alexandra I Soto-BeasleyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Shunsuke KogaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Yingxue RenDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
Michael G HeckmanDivision of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.
Lukasz M MilanowskiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, Poland; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Rebecca R ValentinoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Naveen KondruDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ryan J UittiDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
William P CheshireDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Mayo Graduate School Neuroscience Track, Mayo Clinic, Jacksonville, FL, USA; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, USA. Electronic address: ross.owen@mayo.edu.
Mayo Clinic in Florida · USWinnMed · USJacksonville College · USMedical University of Warsaw · PL

Funding

Utilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5M
Project 2: Identifying genes and Pathways that impact Tau Toxicity in FTDU54NS100693 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 2016 to 2020
$6.2M
Understanding the role of MAPT in Parkinsonian disordersR01NS078086 · NINDS · MAYO CLINIC JACKSONVILLE · PI ROSS, OWEN A · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS078086NINDS NIH HHS U54 NS100693NINDS NIH HHS U54 NS110435
6 · The paper itself

Abstract

Multiple system atrophy (MSA) is a rare sporadic, progressive parkinsonism characterised by autonomic dysfunction. A recent genome-wide association study reported an association at the Elongation of Very Long Fatty Acids Protein 7 (ELOVL7) locus with MSA risk. In the current study four independent and unrelated cohorts were assessed, consisting of pathologically confirmed MSA cases, Parkinson's disease (PD) cases, and two unrelated, healthy control groups. All exons of ELOVL7 were sequenced in pathologically confirmed MSA cases; data for PPMI samples and Biobank controls was extracted from whole genome sequence. Coding variants in ELOVL7 were extremely rare, and we observed no significant association of ELOVL7 coding variants with risk of MSA.

Indexed as

AdultAgedAged, 80 and overalpha-SynucleinFatty Acid ElongasesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedMultiple System AtrophyParkinson DiseasePolymorphism, Single Nucleotidealpha-SynucleinELOVL7 protein, humanFatty Acid ElongasesELOVL7GeneticsLipidsMultiple system atrophySynucleinopathy

Identifiers

PMID33600908
PMCPMC7983070
OpenAlexW3131814960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.