ArticleJournal of stroke2021
Perfusion and Diffusion Variables Predict Early Neurological Deterioration in Minor Stroke and Large Vessel Occlusion.
Article in Journal of stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perfusion imaging-guided risk stratification and endovascular decision-making in low-NIHSS large-vessel occlusion stroke: a systematic review and exploratory meta-analysis.Journal of neurology · 2026Pooled it
- Effects of endovascular therapy for mild stroke due to proximal or M2 occlusions: meta-analysis.Journal of neurointerventional surgery · 2023Pooled it
- Beyond the total NIHSS score: association between impaired level of consciousness and early neurological deterioration in mild large vessel occlusion stroke.Neuroradiology · 2026Article
- Review
- Association of dynamic changes in ASPECTS perfusion scores derived from dual-time-point multi-post-labeling delay arterial spin labeling with 90-day functional outcome in acute ischemic stroke.American journal of translational research · 2026Article
- Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke.Journal of stroke · 2026Review
- Association of blood pressure parameters on early neurological deterioration in patients with mild stroke and large vessel occlusion following medical management.BMC neurology · 2025Article
- Early neurological deterioration in patients with minor stroke: A single-center study conducted in Vietnam.PloS one · 2025Observational
- Safety and efficacy of rescue endovascular treatment in ischemic stroke patients with early neurological deterioration caused by large vessel occlusion.American journal of translational research · 2025Article
- Rescue therapy of early neurological deterioration in lacunar stroke.BMC neurology · 2024Article
- Article
- Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion.CNS neuroscience & therapeutics · 2023Article
- Association of Perfusion Lesion Variables With Functional Outcome in Patients With Mild Stroke and Large Vessel Occlusion Managed Medically.Neurology · 2023Article
- Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study.Therapeutic advances in neurological disorders · 2023Article
- High serum total cholesterol associated with good outcome in endovascular thrombectomy for acute large artery occlusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Perfusion profile evaluated by severity-weighted multiple Tmax strata predicts early neurological deterioration in minor stroke with large vessel occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Observational
- The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center.Brain sciences · 2022Article
- Biomarker of early neurological deterioration in minor stroke and proximal large vessel occlusion: A pilot study.Frontiers in neurology · 2022Article
- Effectiveness and safety of EVT in patients with acute LVO and low NIHSS.Frontiers in neurology · 2022Article
- Meta-Analysis of Predictive Role of Early Neurological Deterioration after Intravenous Thrombolysis.Emergency medicine international · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with acute large vessel occlusion (LVO) presenting with mild stroke symptoms are at risk of early neurological deterioration (END). This study aimed to identify the optimal imaging variables for predicting END in this population.
methodsWe retrospectively analyzed 94 patients from the prospectively maintained institutional stroke registry admitted between January 2011 and May 2019, presenting within 24 hours after onset, with a baseline National Institutes of Health Stroke Scale score ≤5 and anterior circulation LVO. Patients who underwent endovascular therapy before END were excluded. Volumes of Tmax delay (at >2, >4, >6, >8, and >10 seconds), mismatch (Tmax >4 seconds - diffusion-weighted imaging [DWI] and Tmax >6 seconds - DWI), and mild hypoperfusion lesions (Tmax 2-6 and 4-6 seconds) were measured. The association of each variable with END was examined using receiver operating characteristic curves. The variables with best predictive performance were dichotomized at the cutoff point maximizing Youden's index and subsequently analyzed using multivariable logistic regression.
resultsEND occurred in 39.4% of the participants. The optimal variables were identified as Tmax >6 seconds, Tmax >6 seconds - DWI, and Tmax 4-6 seconds with cut-off points of 53.73, 32.77, and 55.20 mL, respectively. These variables were independently associated with END (adjusted odds ratio [aOR], 12.78 [95% confidence interval (CI), 3.36 to 48.65]; aOR, 5.73 [95% CI, 2.04 to 16.08]; and aOR, 9.13 [95% CI, 2.76 to 30.17], respectively).
conclusionsTmax >6 seconds, Tmax >6 seconds - DWI, and Tmax 4-6 seconds could identify patients at high risk of END following minor stroke due to LVO.
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