Evidence map›Paper›PMID 33600452›Full record

ArticlePloS one2021

Clinical characteristics of IgG4-related retroperitoneal fibrosis versus idiopathic retroperitoneal fibrosis.

Kunkun Wang, Zhenfan Wang, Qiaozhu Zeng, Lijuan Zhu, Jingyuan Gao, Ziqiao Wang, Shanshan Zhang, Fei Yang, Danhua Shen, Yi Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Management of IgG4-Related Disease.Current rheumatology reports · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. A case of type 2 diabetes mellitus complicated with IgG4-related retroperitoneal fibrosis and a literature review.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  10. Article
  11. Article
  12. Reply.Journal of vascular surgery cases and innovative techniques · 2022
    Article
  13. [Immunoglobulin G (IgG) 4-related diseases].Zeitschrift fur Rheumatologie · 2022
    Article
  14. Article
  15. Renal Involvement in Retroperitoneal Fibrosis: Prevalence, Impact and Management Challenges.International journal of nephrology and renovascular disease · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kunkun WangDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Zhenfan WangDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Qiaozhu ZengDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Lijuan ZhuDepartment of Rheumatology and Immunology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Jingyuan GaoDepartment of Geriatrics, Affiliated Hospital of North China University of Technology, Tangshan, China.
Ziqiao WangDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Shanshan ZhangDepartment of Ultrasound, Peking University People's Hospital, Beijing, China.
Fei YangDepartment of Pathology, Peking University People's Hospital, Beijing, China.
Danhua ShenDepartment of Pathology, Peking University People's Hospital, Beijing, China.
Yi WangDepartment of Radiology, Peking University People's Hospital, Beijing, China.
Yanying LiuDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.ORCID 0000-0003-2609-4052
Peking University · CNNorth China University of Technology · CNZhengzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retroperitoneal fibrosis (RPF) is an uncommon condition characterized by inflammation and fibrosis in the retroperitoneal space. More than two-thirds of RPF are idiopathic, with the remaining stemed from a variety of secondary causes. It was suggested that IgG4-related RPF is a secondary form of RPF. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-related RPF and IRPF in a large Chinese cohort. We retrospectively reviewed the medical records of 132 RPF patients diagnosed at Peking University People's Hospital between March 2010 and March 2018. Among the 132 patients, the mean age at disease onset was 54.8 years. IgG4-related RPF group showed greater male predominance compared to IRPF group. IgG4-related RPF patients showed a longer interval between symptom onset and diagnosis, and allergic diseases were more common in this group. Sixty-four patients (48.4%) had lower back pain, which was more common in IRPF group than that in IgG4-related RPF patients. In terms of organ involvement, although 42 of 47 patients (89.3%) with IgG4-related RPF had other organ involvement, there were no patients in the IRPF group with other organ involvement. In addition, the serum IgG4 level, elevated eosinophils counts and IgE level were significantly higher in IgG4-related RPF patients. We described the demographic, clinical and laboratory differences between IgG4-related RPF and IRPF patients, indicating their potential differences in pathogenesis, which was of great importance to diagnose and manage the two phenotypes.

Indexed as

PhenotypeAdultAgedChinaEosinophilsFemaleFollow-Up StudiesHumansImmunoglobulin EImmunoglobulin GLeukocyte CountMaleMiddle AgedPainRetroperitoneal FibrosisRetroperitoneal SpaceImmunoglobulin EImmunoglobulin G

Identifiers

PMID33600452
PMCPMC7891782
OpenAlexW3131337895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.