Evidence map›Paper›PMID 33600229›Full record

ReviewCirculation research2021

Machine Learning in Arrhythmia and Electrophysiology.

Natalia A Trayanova, Dan M Popescu, Julie K Shade

Abstract readReview
In one paragraph

Review in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Efficacy and safety of ventricular tachycardia ablation versus antiarrhythmics in ischemic cardiomyopathy: a network meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
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  15. Article
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  17. Evaluating artificial intelligence-enabled medical tests in cardiology: Best practice.International journal of cardiology. Heart & vasculature · 2025
    Review
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  20. The Electrophysiology Lab of the Future.The Journal of innovations in cardiac rhythm management · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia A TrayanovaDepartment of Biomedical Engineering (N.A.T., J.K.S.), Johns Hopkins University, Baltimore, MD.
Dan M PopescuAlliance for Cardiovascular Diagnosis and Treatment Innovation, Whiting School of Engineering and School of Medicine (N.A.T., D.M.P., J.K.S.), Johns Hopkins University, Baltimore, MD.
Julie K ShadeDepartment of Biomedical Engineering (N.A.T., J.K.S.), Johns Hopkins University, Baltimore, MD.

Funding

Simulation Guidance of Ablation Therapy for Persistent Atrial FibrillationU01HL141074 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CALKINS, HUGH G, TRAYANOVA, NATALIA A. · 2018 to 2021
$3.1M
Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Implications of Intra-Myocardial Fat Deposition upon Propensity for Malignant ArrhythmiaR01HL142893 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN, TRAYANOVA, NATALIA A. · 2018 to 2021
$2.5M
Role of dual-specificity phosphatase 5 (DUSP5) in the regulation of right ventricF32HL124893 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FERGUSON, BRADLEY S · 2014 to 2015
$77k
NHLBI NIH HHS F32 HL124893NHLBI NIH HHS R01 HL142496NHLBI NIH HHS R01 HL142893NHLBI NIH HHS U01 HL141074
6 · The paper itself

Abstract

Machine learning (ML), a branch of artificial intelligence, where machines learn from big data, is at the crest of a technological wave of change sweeping society. Cardiovascular medicine is at the forefront of many ML applications, and there is a significant effort to bring them into mainstream clinical practice. In the field of cardiac electrophysiology, ML applications have also seen a rapid growth and popularity, particularly the use of ML in the automatic interpretation of ECGs, which has been extensively covered in the literature. Much lesser known are the other aspects of ML application in cardiac electrophysiology and arrhythmias, such as those in basic science research on arrhythmia mechanisms, both experimental and computational; in the development of better techniques for mapping of cardiac electrical function; and in translational research related to arrhythmia management. In the current review, we examine comprehensively such ML applications as they match the scope of this journal. The current review is organized in 3 parts. The first provides an overview of general ML principles and methodologies that will afford readers of the necessary information on the subject, serving as the foundation for inviting further ML applications in arrhythmia research. The basic information we provide can serve as a guide on how one might design and conduct an ML study. The second part is a review of arrhythmia and electrophysiology studies in which ML has been utilized, highlighting the broad potential of ML approaches. For each subject, we outline comprehensively the general topics, while reviewing some of the research advances utilizing ML under the subject. Finally, we discuss the main challenges and the perspectives for ML-driven cardiac electrophysiology and arrhythmia research.

Indexed as

Machine LearningAnimalsArrhythmias, CardiacDecision Support Systems, ClinicalElectrophysiologic Techniques, CardiacHumansModels, Cardiovasculararrhythmias, cardiacartificial intelligenceatrial fibrillationelectrophysiologymachine learning

Identifiers

PMID33600229
PMCPMC7899082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.