Evidence map›Paper›PMID 33600071›Full record

ArticlePhysiological reports2021

The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro.

Yuko Kuwahara, Ikuo Kato, Toshio Inui, Yoshinori Marunaka, Atsukazu Kuwahara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Physiological roles of chloride ions in bodily and cellular functions.The journal of physiological sciences : JPS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yuko KuwaharaDepartment of Molecular cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ikuo KatoDepartment of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan.
Toshio InuiSaisei Mirai Clinics, Moriguchi, Japan.
Yoshinori MarunakaDepartment of Molecular cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Atsukazu KuwaharaResearch Unit for Epithelial Physiology, Research Center for Drug Discovery and Pharmaceutical Development Science, Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Japan.ORCID 0000-0001-8656-8761
Ritsumeikan University · JPKobe Pharmaceutical University · JPMirai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xenin25 has a variety of physiological functions in the Gastrointestinal (GI) tract, including ion transport and motility. However, the motility responses in the colon induced by Xenin25 remain poorly understood. Therefore, the effect of Xenin25 on the spontaneous circular muscle contractions of the rat distal colon was investigated using organ bath chambers and immunohistochemistry. Xenin25 induced the inhibition followed by postinhibitory spontaneous contractions with a higher frequency in the rat distal colon. This inhibitory effect of Xenin25 was significantly suppressed by TTX but not by atropine. The inhibitory time (the duration of inhibition) caused by Xenin25 was shortened by the NTSR1 antagonist SR48692, the NK1R antagonist CP96345, the VPAC2 receptor antagonist PG99-465, the nitric oxide-sensitive guanylate-cyclase inhibitor ODQ, and the Ca

Indexed as

AnimalsColonEnteric Nervous SystemGastrointestinal AgentsGastrointestinal MotilityIn Vitro TechniquesMaleMuscle ContractionMuscle, SkeletalNeural InhibitionNeurotensinNitrergic NeuronsRatsRats, Sprague-DawleyReceptors, NeurotensinSubstance PGastrointestinal AgentsNeurotensinneurotensin type 1 receptorReceptors, NeurotensinSubstance PVasoactive Intestinal Peptidexenin 25enteric nervous systemintestinal motilitysmooth muscle cellXenin25

Identifiers

PMID33600071
PMCPMC7891183
OpenAlexW3132975636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.