Evidence map›Paper›PMID 33599966›Full record

SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2021

Therapeutic Variation in Lowering Blood Pressure: Effects on Intracranial Pressure in Acute Intracerebral Haemorrhage.

Meeriam Kadicheeni, Thompson G Robinson, Pip Divall, Adrian R Parry-Jones, Jatinder S Minhas

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Meeriam KadicheeniCerebral Haemodynamics in Ageing and Stroke Medicine (CHIASM) Cardiovascular Sciences Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. mk603@le.ac.uk.ORCID http://orcid.org/0000-0002-4383-3622
Thompson G RobinsonCerebral Haemodynamics in Ageing and Stroke Medicine (CHIASM) Cardiovascular Sciences Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Pip DivallUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Adrian R Parry-JonesDivision of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester, UK.
Jatinder S MinhasCerebral Haemodynamics in Ageing and Stroke Medicine (CHIASM) Cardiovascular Sciences Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
University of Leicester · GBManchester Academic Health Science Centre · GBUniversity Hospitals of Leicester NHS Trust · GB

Funding

National Institute for Health Research NIHR Academic Clinical FellowNational Institute for Health Research NIHR Clinical Lecturer in Older People and Complex Health NeedsNational Institute for Health Research NIHR Clinician ScientistNational Institute for Health Research NIHR Senior InvestigatorThe Dunhill Medical Trust RTF97/0117
6 · The paper itself

Abstract

introductionIntracerebral haemorrhage (ICH) is associated with high morbidity and mortality. Blood pressure (BP) control is one of the main management strategies in acute ICH. Limited data currently exist regarding intracranial pressure (ICP) in acute ICH. The relationship between BP lowering and ICP is yet to be fully elucidated.

methodsWe conducted a systematic review to investigate the effects of BP lowering on ICP in acute ICH. The study protocol was registered on PROSPERO (CRD42019134470).

resultsFollowing PRISMA guidelines, MEDLINE, EMBASE and CENTRAL were searched for studies on ICH with BP and ICP or surrogate measures. 1096 articles were identified after duplicates were removed; 18 studies meeting the inclusion criteria. Dihydropyridine calcium channel blockers (CCBs) were the most common agent used to lower BP, but had a varying effect on ICP. Other BP-lowering agents used also had a varying effect on ICP. DISCUSSION AND

conclusionFurther work, including large observational or randomized interventional studies, is needed to develop a better understanding of the effect of BP lowering on ICP in acute ICH, which will assist the development of more effective management strategies.

trial registrationThe study protocol was registered on PROSPERO (CRD42019134470) on 29/05/2019.

Indexed as

AdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCerebral HemorrhageFemaleHumansIntracranial PressureMaleMiddle AgedTreatment OutcomeYoung AdultAntihypertensive AgentsBlood pressureInterventionIntracerebral haemorrhageIntracranial pressureStroke

Identifiers

PMID33599966
OpenAlexW3132180085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.