ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prognostic interplay between cardiac allograft vasculopathy and coronary vascular function by hybrid rubidium-82 PET/CT imaging in heart transplant population.European journal of nuclear medicine and molecular imaging · 2026Article
- Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.Cardiovascular diabetology · 2025Observational
- Computed tomography-based assessment of pericoronary adipose tissue in cardiovascular diseases: Diagnostic and prognostic implications.World journal of radiology · 2025Review
- Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2025Article
- Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives.Reviews in cardiovascular medicine · 2025Review
- Coronary Microvascular Dysfunction Years After Cessation of Anabolic Androgenic Steroid Use.JAMA network open · 2024Article
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Interaction of impaired myocardial flow reserve and extent of myocardial ischemia assessed usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Including myocardial flow reserve by PET in prediction models: Ready to fly?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The Role of Cardiac PET in Diagnosis and Prognosis of Ischemic Heart Disease: Optimal Modality Across Different Patient Populations.Current atherosclerosis reports · 2023Review
- Prediction of outcome byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging.Cardiovascular diabetology · 2023Article
- Low Quantitative Blush Evaluator score predicts larger infarct size and reduced left ventricular systolic function in patients with STEMI regardless of diabetes status.Scientific reports · 2023Observational
- Atherosclerosis Burdens in Diabetes Mellitus: Assessment by PET Imaging.International journal of molecular sciences · 2022Review
- Comparing left ventricular mechanical dyssynchrony between diabetic and non-diabetic patients with normal gated SPECT MPI.The international journal of cardiovascular imaging · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe assessed the prognostic value of structural abnormalities and coronary vasodilator function in diabetic patients referred to a PET/CT for suspected coronary artery disease (CAD).
methodsWe studied 451 diabetics and 451 nondiabetics without overt CAD and normal myocardial perfusion. Myocardial blood flow (MBF) was computed from the dynamic rest and stress imaging. Myocardial flow reserve (MFR) was defined as ratio of hyperemic to baseline MBF and was considered reduced when < 2.
resultsDuring a mean follow-up of 44 months 33 events occurred. Annualized event rate (AER) was higher in diabetic than nondiabetic patients (1.4% vs 0.3%, P < .001). Diabetic patients with reduced MFR had higher AER compared to those with preserved MFR (3.3% vs 0.4%, P < .001). At Cox analysis, age, BMI and reduced MFR were independent predictors of events in diabetic patients. Patients with diabetes and reduced MFR had lower event-free survival compared to nondiabetic patients and MFR < 2 (P < .001). Event-free survival was similar in patients with diabetes and normal MFR and those without diabetes and reduced MFR.
conclusionsDiabetic patients with reduced MFR had higher AER and lower event-free survival compared to those with preserved MFR and to nondiabetic patients.
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