Evidence map›Paper›PMID 33599807›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Post-operative seizure after first time endoscopic third ventriculostomy in pediatric patients.

A S Barkley, S Boop, J K Barber, A Lee, S R Browd, J G Ojemann, R G Ellenbogen, J S Hauptman

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Analysis of the risk factors of post-operative seizure in pediatric patients with hydrocephalus undergoing endoscopic third ventriculostomy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A S BarkleyDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA. respub3@uw.edu.
S BoopDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
J K BarberDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
A LeeDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
S R BrowdDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
J G OjemannDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
R G EllenbogenDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
J S HauptmanDepartment of Neurological Surgery, University of Washington, Box 359924, 325 Ninth Avenue, Seattle, WA, 98104, USA.
Neurological Surgery · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePost-operative seizure rates after endoscopic third ventriculostomy (ETV) are not definitively known. We analyzed our institution's experience for all causes of hydrocephalus in pediatric patients undergoing ETV to determine rates of post-ETV seizure.

methodsA retrospective review of institutional pediatric patients undergoing ETV from May 2014 to December 2018. Included were < 21 years, with 1-year follow-up. Exclusion criteria included ventriculoperitoneal shunts (VPS) prior to ETV, VPS within 7 days post-ETV, and prior seizure disorder. Data included age, gender, diagnosis, early post-operative seizure (within 7 days post-ETV), late post-operative seizures (after first 7 days and within first year post-ETV), concomitant choroid plexus cauterization (CPC), VPS conversion within 1 year, and administration of prophylactic antiepileptics.

resultsSixty of 81 ETV cases were included; 41% underwent concomitant CPC. Of these, 53% (n = 32) were male, 46% (n = 28) female, averaging 5.8 years, with the most common diagnosis neoplasm-related obstructive hydrocephalus (38.3%, n = 23). Early post-operative seizure occurred in 6.7% (n = 4); late post-operative seizure occurred in 8.3% (n = 5). Late post-operative seizures were higher in patients experiencing early post-operative seizure versus those without (75% vs 3.7%, p = 0.003). Late post-operative seizure occurred in 13.6% (n = 3 patients) requiring VPS versus 5.3% (n = 2 patients) with successful ETV (p = 0.36). Rates did not correlate with pathology. No patients received prophylactic antiepileptics prior to surgery or exhibiting a seizure.

conclusionsPatients with early post-operative seizures have an increased likelihood of developing late post-operative seizures. Pediatric ETV patients may have a lower rate of both early and late post-operative seizure; underlying pathology may influence these rates.

Indexed as

HydrocephalusNeuroendoscopyThird VentricleChildFemaleHumansInfantMaleRetrospective StudiesSeizuresTreatment OutcomeVentriculostomyEndoscopic third ventriculostomyHydrocephalusPediatricPost-operativeSeizure

Identifiers

PMID33599807
OpenAlexW3131432939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.