Evidence map›Paper›PMID 33599734›Full record

ArticleInvestigative ophthalmology & visual science2021

The Flash-lag Effect in Amblyopia.

Xi Wang, Alexandre Reynaud, Robert F Hess

Open access · goldAbstract read
In one paragraph

Article in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Integration of Visual Motion Signals in Reduced Visual Conditions.Investigative ophthalmology & visual science · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Measuring the Interocular Delay and its Link to Visual Acuity in Amblyopia.Investigative ophthalmology & visual science · 2024
    Article
  9. Article
  10. Article
  11. Delayed Correction for Extrapolation in Amblyopia.Investigative ophthalmology & visual science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xi WangDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Alexandre ReynaudMcGill Vision Research Unit, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Robert F HessMcGill Vision Research Unit, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
McGill University · CASichuan University · CN

Funding

CIHR CCI-125686
6 · The paper itself

Abstract

Purpose: Amblyopes suffer a defect in temporal processing, presumably because of a neural delay in their visual processing. By measuring flash-lag effect (FLE), we investigate whether the amblyopic visual system could compensate for the intrinsic neural delay due to visual information transmissions from the retina to the cortex. Methods: Eleven adults with amblyopia and 11 controls with normal vision participated in this study. We assessed the monocular FLE magnitude for each subject by using a typical FLE paradigm: a bar moved horizontally, while a flashed bar briefly appeared above or below it. Three luminance contrasts of the flashed bar were tested: 0.2, 0.6, and 1. Results: All participants, controls and those with amblyopia, showed a typical FLE. However, the FLE magnitude of participants with amblyopia was significantly shorter than that of the control participants, for both their amblyopic eye (AE) and fellow eye (FE). A nonsignificant difference was found in FLE magnitude between the AE and the FE. Conclusions: We demonstrate a reduced FLE both in the AE as well as the FE of patients with amblyopia, suggesting a global visual processing deficit. We suggest it may be attributed to a more limited spatiotemporal extent of facilitatory anticipatory activity within the amblyopic primary visual cortex.

Indexed as

Visual AcuityAdultAgedAmblyopiaFemaleHumansMaleMiddle AgedRetinaVisual CortexYoung Adult

Identifiers

PMID33599734
PMCPMC7900860
OpenAlexW3132587557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.