ArticleeLife2021
Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum.Experimental physiology · 2026Article
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus.Nature neuroscience · 2026Article
- Global and local nature of cortical slow waves.iScience · 2025Article
- Article
- Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.Cell reports · 2025Article
- Investigation of a chondroitin sulfate-based bioactive coating for neural interface applications.Journal of materials chemistry. B · 2024Article
- Comparative rhythmic transcriptome profiling of human and mouse striatal subregions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Towards Standardizing Nomenclature in Huntington's Disease Research.Journal of Huntington's disease · 2024Review
- GABAergic regulation of striatal spiny projection neurons depends upon their activity state.PLoS biology · 2024Article
- Callosal inputs generate side-invariant receptive fields in the barrel cortex.Science advances · 2023Article
- Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.Cell reports · 2023Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Ongoing movement controls sensory integration in the dorsolateral striatum.Nature communications · 2023Article
- Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Striatal Direct Pathway Targets Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum.eLife · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral studies differentiate the rodent dorsal striatum (DS) into lateral and medial regions; however, anatomical evidence suggests that it is a unified structure. To understand striatal dynamics and basal ganglia functions, it is essential to clarify the circuitry that supports this behavioral-based segregation. Here, we show that the mouse DS is made of two non-overlapping functional circuits divided by a boundary. Combining in vivo optopatch-clamp and extracellular recordings of spontaneous and evoked sensory activity, we demonstrate different coupling of lateral and medial striatum to the cortex together with an independent integration of the spontaneous activity, due to particular corticostriatal connectivity and local attributes of each region. Additionally, we show differences in slow and fast oscillations and in the electrophysiological properties between striatonigral and striatopallidal neurons. In summary, these results demonstrate that the rodent DS is segregated in two neuronal circuits, in homology with the caudate and putamen nuclei of primates.
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